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Complete Genome Sequence of the Frog Pathogen Mycobacterium ulcerans Ecovar Liflandii

Overview of attention for article published in Journal of Bacteriology, November 2012
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  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

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1 X user
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1 Facebook page
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2 Wikipedia pages

Citations

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46 Dimensions

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79 Mendeley
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Title
Complete Genome Sequence of the Frog Pathogen Mycobacterium ulcerans Ecovar Liflandii
Published in
Journal of Bacteriology, November 2012
DOI 10.1128/jb.02132-12
Pubmed ID
Authors

Nicholas J. Tobias, Kenneth D. Doig, Marnix H. Medema, Honglei Chen, Volker Haring, Robert Moore, Torsten Seemann, Timothy P. Stinear

Abstract

In 2004, a previously undiscovered mycobacterium resembling Mycobacterium ulcerans (the agent of Buruli ulcer) was reported in an outbreak of a lethal mycobacteriosis in a laboratory colony of the African clawed frog Xenopus tropicalis. This mycobacterium makes mycolactone and is one of several strains of M. ulcerans-like mycolactone-producing mycobacteria recovered from ectotherms around the world. Here, we describe the complete 6,399,543-bp genome of this frog pathogen (previously unofficially named "Mycobacterium liflandii"), and we show that it has undergone an intermediate degree of reductive evolution between the M. ulcerans Agy99 strain and the fish pathogen Mycobacterium marinum M strain. Like M. ulcerans Agy99, it has the pMUM mycolactone plasmid, over 200 chromosomal copies of the insertion sequence IS2404, and a high proportion of pseudogenes. However, M. liflandii has a larger genome that is closer in length, sequence, and architecture to M. marinum M than to M. ulcerans Agy99, suggesting that the M. ulcerans Agy99 strain has undergone accelerated evolution. Scrutiny of the genes specifically lost suggests that M. liflandii is a tryptophan, tyrosine, and phenylalanine auxotroph. A once-extensive M. marinum-like secondary metabolome has also been diminished through reductive evolution. Our analysis shows that M. liflandii, like M. ulcerans Agy99, has the characteristics of a niche-adapted mycobacterium but also has several distinctive features in important metabolic pathways that suggest that it is responding to different environmental pressures, supporting earlier proposals that it could be considered an M. ulcerans ecotype, hence the name M. ulcerans ecovar Liflandii.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Unknown 78 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 18%
Researcher 11 14%
Student > Master 11 14%
Student > Bachelor 9 11%
Student > Doctoral Student 6 8%
Other 17 22%
Unknown 11 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 27%
Biochemistry, Genetics and Molecular Biology 13 16%
Veterinary Science and Veterinary Medicine 6 8%
Medicine and Dentistry 5 6%
Chemistry 5 6%
Other 14 18%
Unknown 15 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2018.
All research outputs
#7,778,730
of 25,374,917 outputs
Outputs from Journal of Bacteriology
#5,831
of 16,901 outputs
Outputs of similar age
#76,130
of 285,604 outputs
Outputs of similar age from Journal of Bacteriology
#28
of 108 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 16,901 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,604 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.