| Title |
Transition metal abnormalities in progressive dementias
|
|---|---|
| Published in |
BioMetals, November 2011
|
| DOI | 10.1007/s10534-011-9504-8 |
| Pubmed ID | |
| Authors |
Hiroyasu Akatsu, Akira Hori, Takayuki Yamamoto, Mari Yoshida, Maya Mimuro, Yoshio Hashizume, Ikuo Tooyama, Eric M. Yezdimer |
| Abstract |
Abnormal distributions of transition metals inside the brain are potential diagnostic markers for several central nervous system diseases, including Alzheimer's disease (AD), Parkinson's disease, dementia with Lewy bodies (DLB), bipolar disorders and depression. To further explore this possibility, the total concentrations of iron, zinc, copper, manganese, aluminum, chromium and cadmium were measured in post-mortem hippocampus and amygdala tissues taken from AD, DLB and Control patients. A statistically significant near fifty percent reduction in the total copper levels of AD patients was observed in both the hippocampus and amygdala. The statistical power of the hippocampus and amygdala copper analysis was found to be 86 and 74% respectively. No statistically significant deviations in the total metal concentrations were found for zinc, manganese, chromium or aluminum. Iron was found to be increased by 38% in AD amygdala tissues, but was unchanged in AD hippocampus tissues. Accounting for differences in tissue water content, as a function of both tissue type and disease state, revealed more consistencies with previous literature. To aid in the design of future experiments, the effect sizes for all tissue types and metals studied are also presented. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Chile | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 73 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 14% |
| Other | 8 | 10% |
| Researcher | 8 | 10% |
| Student > Ph. D. Student | 8 | 10% |
| Student > Bachelor | 5 | 6% |
| Other | 17 | 22% |
| Unknown | 20 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 25% |
| Agricultural and Biological Sciences | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Neuroscience | 5 | 6% |
| Chemistry | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 24 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2014.
All research outputs
#3,101,400
of 22,689,790 outputs
Outputs from BioMetals
#44
of 641 outputs
Outputs of similar age
#17,628
of 141,940 outputs
Outputs of similar age from BioMetals
#1
of 2 outputs
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So far Altmetric has tracked 641 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 92% of its peers.
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