| Title |
The heart-brain connection: mechanistic insights and models
|
|---|---|
| Published in |
Netherlands Heart Journal, November 2012
|
| DOI | 10.1007/s12471-012-0348-9 |
| Pubmed ID | |
| Authors |
K. Ritz, M. A. van Buchem, M. J. Daemen |
| Abstract |
While both cardiac dysfunction and progressive loss of cognitive function are prominent features of an ageing population, surprisingly few studies have addressed the link between the function of the heart and brain. Recent literature indicates that autoregulation of cerebral flow is not able to protect the brain from hypoperfusion when cardiac output is reduced or atherosclerosis is prominent. This suggests a close link between cardiac function and large vessel atherosclerosis on the one hand and brain perfusion and cognitive functioning on the other. Mechanistically, the presence of vascular pathology leads to chronic cerebral hypoperfusion, blood brain barrier breakdown and inflammation that most likely precede neuronal death and neurodegeneration. Animal models to study the effects of chronic cerebral hypoperfusion are available, but they have not yet been combined with cardiovascular models. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 15% |
| Mexico | 3 | 15% |
| United States | 2 | 10% |
| Netherlands | 1 | 5% |
| India | 1 | 5% |
| Venezuela, Bolivarian Republic of | 1 | 5% |
| Argentina | 1 | 5% |
| Spain | 1 | 5% |
| Colombia | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 6 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 60% |
| Practitioners (doctors, other healthcare professionals) | 3 | 15% |
| Scientists | 3 | 15% |
| Science communicators (journalists, bloggers, editors) | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Switzerland | 1 | 1% |
| Germany | 1 | 1% |
| Canada | 1 | 1% |
| Netherlands | 1 | 1% |
| Unknown | 68 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 16% |
| Student > Master | 11 | 15% |
| Student > Bachelor | 7 | 9% |
| Student > Doctoral Student | 7 | 9% |
| Student > Postgraduate | 7 | 9% |
| Other | 16 | 22% |
| Unknown | 14 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 34% |
| Neuroscience | 11 | 15% |
| Agricultural and Biological Sciences | 10 | 14% |
| Computer Science | 3 | 4% |
| Psychology | 3 | 4% |
| Other | 7 | 9% |
| Unknown | 15 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2019.
All research outputs
#3,291,688
of 25,366,663 outputs
Outputs from Netherlands Heart Journal
#55
of 556 outputs
Outputs of similar age
#30,994
of 289,594 outputs
Outputs of similar age from Netherlands Heart Journal
#7
of 19 outputs
Altmetric has tracked 25,366,663 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 556 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,594 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.