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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Altered Functional Brain Connectivity in a Non-Clinical Sample of Young Adults with Attention-Deficit/Hyperactivity Disorder
|
|---|---|
| Published in |
Journal of Neuroscience, December 2012
|
| DOI | 10.1523/jneurosci.3272-12.2012 |
| Pubmed ID | |
| Authors |
Luca Cocchi, Ivanei E. Bramati, Andrew Zalesky, Emi Furukawa, Leonardo F. Fontenelle, Jorge Moll, Gail Tripp, Paulo Mattos |
| Abstract |
Attention-deficit/hyperactivity disorder (ADHD) is characterized by symptoms of inattention and hyperactivity/impulsivity that often persist in adulthood. There is a growing consensus that ADHD is associated with abnormal function of diffuse brain networks, but such alterations remain poorly characterized. Using resting-state functional magnetic resonance imaging, we characterized multivariate (complex network measures), bivariate (network-based statistic), and univariate (regional homogeneity) properties of brain networks in a non-clinical, drug-naive sample of high-functioning young men and women with ADHD (nine males, seven females) and a group of matched healthy controls. Data from our sample allowed the isolation of intrinsic functional connectivity alterations specific to ADHD diagnosis and symptoms that are not related to developmental delays, general cognitive dysfunction, or history of medication use. Multivariate results suggested that frontal, temporal, and occipital cortices were abnormally connected locally as well as with the rest of the brain in individuals with ADHD. Results from the network-based statistic support and extend multivariate results by isolating two brain networks comprising regions between which inter-regional connectivity was significantly altered in the ADHD group; namely, a frontal amygdala-occipital network and a frontal temporal-occipital network. Brain behavior correlations further highlighted the key role of altered orbitofrontal-temporal and frontal-amygdala connectivity for symptoms of inattention and hyperactivity/impulsivity. All univariate properties were similar between groups. Taken together, results from this study show that the diagnosis and the two main symptom dimensions of ADHD are related to altered intrinsic connectivity in orbitofrontal-temporal-occipital and fronto-amygdala-occipital networks. Accordingly, our findings highlight the importance of extending the conceptualization of ADHD beyond segregated fronto-striatal alterations. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 225 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Netherlands | 2 | <1% |
| United Kingdom | 2 | <1% |
| Turkey | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 216 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 55 | 24% |
| Researcher | 38 | 17% |
| Student > Master | 34 | 15% |
| Student > Bachelor | 18 | 8% |
| Student > Doctoral Student | 13 | 6% |
| Other | 33 | 15% |
| Unknown | 34 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 55 | 24% |
| Medicine and Dentistry | 34 | 15% |
| Neuroscience | 30 | 13% |
| Agricultural and Biological Sciences | 20 | 9% |
| Engineering | 10 | 4% |
| Other | 24 | 11% |
| Unknown | 52 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2013.
All research outputs
#17,113,512
of 25,142,442 outputs
Outputs from Journal of Neuroscience
#19,417
of 24,037 outputs
Outputs of similar age
#193,173
of 290,732 outputs
Outputs of similar age from Journal of Neuroscience
#242
of 356 outputs
Altmetric has tracked 25,142,442 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,037 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,732 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 356 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.