| Title |
A significant relationship between mercury exposure from dental amalgams and urinary porphyrins: a further assessment of the Casa Pia children’s dental amalgam trial
|
|---|---|
| Published in |
BioMetals, November 2010
|
| DOI | 10.1007/s10534-010-9387-0 |
| Pubmed ID | |
| Authors |
David A. Geier, Thomas Carmody, Janet K. Kern, Paul G. King, Mark R. Geier |
| Abstract |
Previous studies noted specific changes in urinary porphyrin excretion patterns associated with exposure to mercury (Hg) in animals and humans. In our study, urinary porphyrin concentrations were examined in normal children 8-18 years-old from a reanalysis of data provided from a randomized, prospective clinical trial that was designed to evaluate the potential health consequences of prolonged exposure to Hg from dental amalgam fillings (the parent study). Our analysis examined dose-dependent correlations between increasing Hg exposure from dental amalgams and urinary porphyrins utilizing statistical models with adjustments for the baseline level (i.e. study year 1) of the following variables: urinary Hg, each urinary porphyrin measure, gender, race, and the level of lead (Pb) in each subject's blood. Significant dose-dependent correlations between cumulative exposure to Hg from dental amalgams and urinary porphyrins associated with Hg body-burden (pentacarboxyporphyrin, precoproporphyrin, and coproporphyrin) were observed. Overall, 5-10% increases in Hg-associated porphyrins for subjects receiving an average number of dental amalgam fillings in comparison to subjects receiving only composite fillings were observed over the 8-year course of the study. In contrast, no significant correlations were observed between cumulative exposure to Hg from dental amalgams and urinary porphyrins not associated with Hg body-burden (uroporphyrin, heptacarboxyporphyrin, and hexacarboxyporphyrin). In conclusion, our study, in contrast to the no-effect results published from the parent study, further establishes the sensitivity and specificity of specific urinary porphyrins as a biomarker for low-level Hg body-burden, and also reveals that dental amalgams are a significant chronic contributor to Hg body-burden. |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 2% |
| Unknown | 46 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 23% |
| Researcher | 9 | 19% |
| Student > Master | 4 | 9% |
| Professor | 3 | 6% |
| Student > Ph. D. Student | 3 | 6% |
| Other | 9 | 19% |
| Unknown | 8 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 36% |
| Nursing and Health Professions | 5 | 11% |
| Agricultural and Biological Sciences | 3 | 6% |
| Environmental Science | 3 | 6% |
| Chemistry | 2 | 4% |
| Other | 8 | 17% |
| Unknown | 9 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2022.
All research outputs
#5,007,285
of 24,549,201 outputs
Outputs from BioMetals
#89
of 678 outputs
Outputs of similar age
#21,548
of 104,602 outputs
Outputs of similar age from BioMetals
#1
of 7 outputs
Altmetric has tracked 24,549,201 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 678 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done well, scoring higher than 87% of its peers.
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We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them