Title |
HPV Status of Oropharyngeal Cancer by Combination HPV DNA/p16 Testing: Biological Relevance of Discordant Results
|
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Published in |
Annals of Surgical Oncology, December 2012
|
DOI | 10.1245/s10434-012-2778-4 |
Pubmed ID | |
Authors |
Angela Hong, Deanna Jones, Mark Chatfield, C. Soon Lee, Mei Zhang, Jonathan Clark, Michael Elliott, Gerald Harnett, Christopher Milross, Barbara Rose |
Abstract |
Human papillomavirus (HPV) causes up to 70 % of oropharyngeal cancers (OSCC). HPV positive OSCC has a more favorable outcome, thus HPV status is being used to guide treatment and predict outcome. Combination HPV DNA/p16(ink4) (p16) testing is commonly used for HPV status, but there are no standardized methods, scoring or interpretative criteria. The significance of discordant (HPV DNA positive/p16 negative and HPV DNA negative/p16 positive) cancers is controversial. In this study, 647 OSCCs from 10 Australian centers were tested for HPV DNA/p16 expression. Our aims are to determine p16 distribution by HPV DNA status to inform decisions on p16 scoring and to assess clinical significance of discordant cancers. |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 13% |
Student > Doctoral Student | 4 | 13% |
Librarian | 3 | 10% |
Professor | 2 | 6% |
Student > Bachelor | 2 | 6% |
Other | 9 | 29% |
Unknown | 7 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 18 | 58% |
Agricultural and Biological Sciences | 2 | 6% |
Social Sciences | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Unknown | 8 | 26% |