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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Alzheimer's disease: the cholesterol connection
|
|---|---|
| Published in |
Nature Neuroscience, April 2003
|
| DOI | 10.1038/nn0403-345 |
| Pubmed ID | |
| Authors |
Luigi Puglielli, Rudolph E. Tanzi, Dora M. Kovacs |
| Abstract |
A hallmark of all forms of Alzheimer's disease (AD) is an abnormal accumulation of the beta-amyloid protein (Abeta) in specific brain regions. Both the generation and clearance of Abeta are regulated by cholesterol. Elevated cholesterol levels increase Abeta in cellular and most animals models of AD, and drugs that inhibit cholesterol synthesis lower Abeta in these models. Recent studies show that not only the total amount, but also the distribution of cholesterol within neurons, impacts Abeta biogenesis. The identification of a variant of the apolipoprotein E (APOE) gene as a major genetic risk factor for AD is also consistent with a role for cholesterol in the pathogenesis of AD. Clinical trials have recently been initiated to test whether lowering plasma and/or neuronal cholesterol levels is a viable strategy for treating and preventing AD. In this review, we describe recent findings concerning the molecular mechanisms underlying the cholesterol-AD connection. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 40% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 445 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 1% |
| United Kingdom | 3 | <1% |
| Switzerland | 1 | <1% |
| Netherlands | 1 | <1% |
| India | 1 | <1% |
| Germany | 1 | <1% |
| Chile | 1 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 431 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 84 | 19% |
| Student > Bachelor | 74 | 17% |
| Researcher | 60 | 13% |
| Student > Master | 49 | 11% |
| Student > Doctoral Student | 28 | 6% |
| Other | 72 | 16% |
| Unknown | 78 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 87 | 20% |
| Neuroscience | 65 | 15% |
| Biochemistry, Genetics and Molecular Biology | 63 | 14% |
| Medicine and Dentistry | 41 | 9% |
| Chemistry | 25 | 6% |
| Other | 68 | 15% |
| Unknown | 96 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 51. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2023.
All research outputs
#844,672
of 26,017,215 outputs
Outputs from Nature Neuroscience
#1,465
of 5,702 outputs
Outputs of similar age
#717
of 65,610 outputs
Outputs of similar age from Nature Neuroscience
#1
of 39 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,702 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 57.9. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 65,610 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.