| Title |
Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies
|
|---|---|
| Published in |
Archivum Immunologiae et Therapiae Experimentalis, December 2012
|
| DOI | 10.1007/s00005-012-0203-0 |
| Pubmed ID | |
| Authors |
Sameer Agnihotri, Kelly E. Burrell, Amparo Wolf, Sharzhad Jalali, Cynthia Hawkins, James T. Rutka, Gelareh Zadeh |
| Abstract |
Glioblastoma (GBM) is the most common and lethal primary brain tumor. Over the past few years tremendous genomic and proteomic characterization along with robust animal models of GBM have provided invaluable data that show that "GBM", although histologically indistinguishable from one another, are comprised of molecularly heterogenous diseases. In addition, robust pre-clinical models and a better understanding of the core pathways disrupted in GBM are providing a renewed optimism for novel strategies targeting these devastating tumors. Here, we summarize a brief history of the disease, our current molecular knowledge, lessons from animal models and emerging concepts of angiogenesis, invasion, and metabolism in GBM that may lend themselves to therapeutic targeting. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 486 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | <1% |
| Brazil | 2 | <1% |
| Hungary | 1 | <1% |
| Italy | 1 | <1% |
| Turkey | 1 | <1% |
| United Kingdom | 1 | <1% |
| New Zealand | 1 | <1% |
| Mexico | 1 | <1% |
| Nigeria | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 474 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 85 | 17% |
| Student > Master | 82 | 17% |
| Student > Bachelor | 77 | 16% |
| Researcher | 44 | 9% |
| Student > Doctoral Student | 25 | 5% |
| Other | 50 | 10% |
| Unknown | 123 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 94 | 19% |
| Medicine and Dentistry | 82 | 17% |
| Agricultural and Biological Sciences | 79 | 16% |
| Neuroscience | 27 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 20 | 4% |
| Other | 57 | 12% |
| Unknown | 127 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2020.
All research outputs
#6,385,333
of 22,689,790 outputs
Outputs from Archivum Immunologiae et Therapiae Experimentalis
#78
of 386 outputs
Outputs of similar age
#67,086
of 277,812 outputs
Outputs of similar age from Archivum Immunologiae et Therapiae Experimentalis
#2
of 6 outputs
Altmetric has tracked 22,689,790 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 386 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,812 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.