Title |
Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers
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Published in |
Diagnostic Pathology, July 2012
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DOI | 10.1186/1746-1596-7-87 |
Pubmed ID | |
Authors |
Leda Guzmán, María Soledad Depix, Ana María Salinas, Rosa Roldán, Francisco Aguayo, Alejandra Silva, Raul Vinet |
Abstract |
Chronic obstructive pulmonary disease (COPD) is a disorder associated to cigarette smoke and lung cancer (LC). Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in the development of LC. In this study, we hypothesize that tobacco smokers are susceptible for methylation in the promoter region of TSGs in airway epithelial cells when compared with non-smoker subjects. The purpose of this study was to investigate the usefulness of detection of genes promoter methylation in sputum specimens, as a complementary tool to identify LC biomarkers among smokers with early COPD. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 2% |
Sweden | 1 | 2% |
Unknown | 53 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 29% |
Researcher | 10 | 18% |
Professor > Associate Professor | 6 | 11% |
Student > Master | 4 | 7% |
Student > Bachelor | 4 | 7% |
Other | 7 | 13% |
Unknown | 8 | 15% |
Readers by discipline | Count | As % |
---|---|---|
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Agricultural and Biological Sciences | 11 | 20% |
Biochemistry, Genetics and Molecular Biology | 11 | 20% |
Immunology and Microbiology | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 7% |
Unknown | 10 | 18% |