Title |
Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes
|
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Published in |
Diabetologia, December 2012
|
DOI | 10.1007/s00125-012-2798-4 |
Pubmed ID | |
Authors |
J. A. Pane, N. L. Webster, K. L. Graham, G. Holloway, C. Zufferey, B. S. Coulson |
Abstract |
Rotavirus infection in at-risk children correlates with production of serum autoantibodies indicative of type 1 diabetes progression. Oral infection with rhesus monkey rotavirus (RRV) accelerates diabetes onset in mice. This relates to their rotavirus-specific serum antibody titre and local pro-inflammatory cytokine induction without pancreatic infection. Our aim was to further investigate the roles of serum antibodies and viral extra-intestinal spread in diabetes acceleration by rotavirus. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 4 | 20% |
Student > Ph. D. Student | 3 | 15% |
Researcher | 3 | 15% |
Other | 2 | 10% |
Student > Bachelor | 1 | 5% |
Other | 2 | 10% |
Unknown | 5 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 30% |
Agricultural and Biological Sciences | 4 | 20% |
Immunology and Microbiology | 3 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Engineering | 1 | 5% |
Other | 0 | 0% |
Unknown | 5 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2012.
All research outputs
#18,323,689
of 22,689,790 outputs
Outputs from Diabetologia
#4,666
of 5,025 outputs
Outputs of similar age
#216,522
of 278,890 outputs
Outputs of similar age from Diabetologia
#27
of 41 outputs
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