| Title |
Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common
|
|---|---|
| Published in |
Malaria Journal, December 2012
|
| DOI | 10.1186/1475-2875-11-418 |
| Pubmed ID | |
| Authors |
Nicholas J White, Li Guo Qiao, Gao Qi, Lucio Luzzatto |
| Abstract |
In areas of low malaria transmission, it is currently recommended that a single dose of primaquine (0.75 mg base/kg; 45 mg adult dose) be added to artemisinin combination treatment (ACT) in acute falciparum malaria to block malaria transmission. Review of studies of transmission-blocking activity based on the infectivity of patients or volunteers to anopheline mosquitoes, and of haemolytic toxicity in glucose 6-dehydrogenase (G6PD) deficient subjects, suggests that a lower primaquine dose (0.25 mg base/kg) would be safer and equally effective. This lower dose could be deployed together with ACTs without G6PD testing wherever use of a specific gametocytocide is indicated. |
Mendeley readers
The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Tanzania, United Republic of | 1 | <1% |
| Indonesia | 1 | <1% |
| Brazil | 1 | <1% |
| United Kingdom | 1 | <1% |
| Thailand | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 161 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 19% |
| Student > Ph. D. Student | 26 | 16% |
| Student > Master | 22 | 13% |
| Other | 15 | 9% |
| Student > Doctoral Student | 11 | 7% |
| Other | 31 | 19% |
| Unknown | 31 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 29% |
| Agricultural and Biological Sciences | 28 | 17% |
| Biochemistry, Genetics and Molecular Biology | 17 | 10% |
| Chemistry | 5 | 3% |
| Immunology and Microbiology | 5 | 3% |
| Other | 28 | 17% |
| Unknown | 36 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2024.
All research outputs
#4,969,136
of 24,400,706 outputs
Outputs from Malaria Journal
#1,234
of 5,827 outputs
Outputs of similar age
#49,532
of 287,628 outputs
Outputs of similar age from Malaria Journal
#19
of 83 outputs
Altmetric has tracked 24,400,706 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,827 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,628 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.