| Title |
Cerebral serotonin transporter asymmetry in females, males and male-to-female transsexuals measured by PET in vivo
|
|---|---|
| Published in |
Brain Structure and Function, December 2012
|
| DOI | 10.1007/s00429-012-0492-4 |
| Pubmed ID | |
| Authors |
Georg S. Kranz, Andreas Hahn, Pia Baldinger, Daniela Haeusler, Cecile Philippe, Ulrike Kaufmann, Wolfgang Wadsak, Markus Savli, Anna Hoeflich, Christoph Kraus, Thomas Vanicek, Markus Mitterhauser, Siegfried Kasper, Rupert Lanzenberger |
| Abstract |
The serotonergic system modulates brain functions that are considered to underlie affective states, emotion and cognition. Several lines of evidence point towards a strong lateralization of these mental processes, which indicates similar asymmetries in associated neurotransmitter systems. Here, our aim was to investigate a potential asymmetry of the serotonin transporter distribution using positron emission tomography and the radioligand [(11)C]DASB in vivo. As brain asymmetries may differ between sexes, we further aimed to compare serotonin transporter asymmetry between females, males and male-to-female (MtF) transsexuals whose brains are considered to be partly feminized. Voxel-wise analysis of serotonin transporter binding in all groups showed both strong left and rightward asymmetries in several cortical and subcortical structures including temporal and frontal cortices, anterior cingulate, hippocampus, caudate and thalamus. Further, male controls showed a rightward asymmetry in the midcingulate cortex, which was absent in females and MtF transsexuals. The present data support the notion of a lateralized serotonergic system, which is in line with previous findings of asymmetric serotonin-1A receptor distributions, extracellular serotonin concentrations, serotonin turnover and uptake. The absence of serotonin transporter asymmetry in the midcingulate in MtF transsexuals may be attributed to an absence of brain masculinization in this region. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 13% |
| United States | 1 | 13% |
| Unknown | 6 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Scientists | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 1% |
| Unknown | 70 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 18% |
| Researcher | 9 | 13% |
| Student > Master | 9 | 13% |
| Student > Bachelor | 6 | 8% |
| Student > Doctoral Student | 6 | 8% |
| Other | 13 | 18% |
| Unknown | 15 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 21 | 30% |
| Medicine and Dentistry | 12 | 17% |
| Agricultural and Biological Sciences | 7 | 10% |
| Neuroscience | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 19 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2024.
All research outputs
#6,307,336
of 25,603,577 outputs
Outputs from Brain Structure and Function
#451
of 2,039 outputs
Outputs of similar age
#59,528
of 287,103 outputs
Outputs of similar age from Brain Structure and Function
#6
of 20 outputs
Altmetric has tracked 25,603,577 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,039 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done well, scoring higher than 77% of its peers.
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.