| Title |
Central Leptin Regulation of Obesity and Fertility
|
|---|---|
| Published in |
Current Obesity Reports, August 2012
|
| DOI | 10.1007/s13679-012-0025-8 |
| Pubmed ID | |
| Authors |
Qingchun Tong, Yong Xu |
| Abstract |
The current obesity epidemic and lack of efficient therapeutics demand a clear understanding of the mechanism underlying body weight regulation. The cloning of leptin, a key body weight regulating adipokine released in proportion to the adipose tissue mass, has revolutionized our understanding of the mechanism by which the body weight is controlled. It is now well established that the brain, especially the hypothalamus, maintains body weight homeostasis by effectively adjusting food intake and energy expenditure in response to changes in levels of various nutritional status indicators, including leptin. In addition, one major defect in physiology associated with obesity is reduced fertility. Defects in leptin action result in both obesity and infertility, suggesting that leptin may serve as a link between nutrition supply and reproduction. This review reports recent research advance in neural pathways underlying leptin action on body weight and fertility, and discusses the remaining outstanding challenges. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Unknown | 55 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 16% |
| Student > Ph. D. Student | 8 | 14% |
| Student > Bachelor | 6 | 11% |
| Professor > Associate Professor | 5 | 9% |
| Student > Master | 5 | 9% |
| Other | 11 | 20% |
| Unknown | 12 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 25% |
| Biochemistry, Genetics and Molecular Biology | 8 | 14% |
| Agricultural and Biological Sciences | 7 | 13% |
| Neuroscience | 4 | 7% |
| Immunology and Microbiology | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 14 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2012.
All research outputs
#20,176,348
of 22,689,790 outputs
Outputs from Current Obesity Reports
#354
of 378 outputs
Outputs of similar age
#133,922
of 149,509 outputs
Outputs of similar age from Current Obesity Reports
#7
of 8 outputs
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