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Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action.

Overview of attention for article published in Pharmacological Reports, January 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog

Citations

dimensions_citation
113 Dimensions

Readers on

mendeley
129 Mendeley
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Title
Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action.
Published in
Pharmacological Reports, January 2008
Pubmed ID
Authors

Bernadeta Szewczyk, Ewa Poleszak, Magdalena Sowa-Kućma, Marcin Siwek, Dominika Dudek, Beata Ryszewska-Pokraśniewicz, Maria Radziwoń-Zaleska, Włodzimierz Opoka, Janusz Czekaj, Andrzej Pilc, Gabriel Nowak

Abstract

The clinical efficacy of current antidepressant therapies is unsatisfactory; antidepressants induce a variety of unwanted effects, and, moreover, their therapeutic mechanism is not clearly understood. Thus, a search for better and safer agents is continuously in progress. Recently, studies have demonstrated that zinc and magnesium possess antidepressant properties. Zinc and magnesium exhibit antidepressant-like activity in a variety of tests and models in laboratory animals. They are active in forced swim and tail suspension tests in mice and rats, and, furthermore, they enhance the activity of conventional antidepressants (e.g., imipramine and citalopram). Zinc demonstrates activity in the olfactory bulbectomy, chronic mild and chronic unpredictable stress models in rats, while magnesium is active in stress-induced depression-like behavior in mice. Clinical studies demonstrate that the efficacy of pharmacotherapy is enhanced by supplementation with zinc and magnesium. The antidepressant mechanisms of zinc and magnesium are discussed in the context of glutamate, brain-derived neurotrophic factor (BDNF) and glycogen synthase kinase-3 (GSK-3) hypotheses. All the available data indicate the importance of zinc and magnesium homeostasis in the psychopathology and therapy of affective disorders.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 2 2%
Austria 1 <1%
Czechia 1 <1%
Brazil 1 <1%
United States 1 <1%
United Kingdom 1 <1%
Unknown 122 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 29 22%
Researcher 19 15%
Student > Ph. D. Student 15 12%
Student > Master 15 12%
Student > Doctoral Student 8 6%
Other 25 19%
Unknown 18 14%
Readers by discipline Count As %
Medicine and Dentistry 29 22%
Agricultural and Biological Sciences 29 22%
Neuroscience 14 11%
Nursing and Health Professions 7 5%
Psychology 7 5%
Other 24 19%
Unknown 19 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2018.
All research outputs
#2,654,844
of 25,377,790 outputs
Outputs from Pharmacological Reports
#52
of 943 outputs
Outputs of similar age
#9,745
of 168,393 outputs
Outputs of similar age from Pharmacological Reports
#2
of 16 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 943 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,393 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.