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Mendeley readers
Attention Score in Context
| Title |
The landscape of histone modifications across 1% of the human genome in five human cell lines
|
|---|---|
| Published in |
Genome Research, June 2007
|
| DOI | 10.1101/gr.5704207 |
| Pubmed ID | |
| Authors |
Christoph M. Koch, Robert M. Andrews, Paul Flicek, Shane C. Dillon, Ulaş Karaöz, Gayle K. Clelland, Sarah Wilcox, David M. Beare, Joanna C. Fowler, Phillippe Couttet, Keith D. James, Gregory C. Lefebvre, Alexander W. Bruce, Oliver M. Dovey, Peter D. Ellis, Pawandeep Dhami, Cordelia F. Langford, Zhiping Weng, Ewan Birney, Nigel P. Carter, David Vetrie, Ian Dunham |
| Abstract |
We generated high-resolution maps of histone H3 lysine 9/14 acetylation (H3ac), histone H4 lysine 5/8/12/16 acetylation (H4ac), and histone H3 at lysine 4 mono-, di-, and trimethylation (H3K4me1, H3K4me2, H3K4me3, respectively) across the ENCODE regions. Studying each modification in five human cell lines including the ENCODE Consortium common cell lines GM06990 (lymphoblastoid) and HeLa-S3, as well as K562, HFL-1, and MOLT4, we identified clear patterns of histone modification profiles with respect to genomic features. H3K4me3, H3K4me2, and H3ac modifications are tightly associated with the transcriptional start sites (TSSs) of genes, while H3K4me1 and H4ac have more widespread distributions. TSSs reveal characteristic patterns of both types of modification present and the position relative to TSSs. These patterns differ between active and inactive genes and in particular the state of H3K4me3 and H3ac modifications is highly predictive of gene activity. Away from TSSs, modification sites are enriched in H3K4me1 and relatively depleted in H3K4me3 and H3ac. Comparison between cell lines identified differences in the histone modification profiles associated with transcriptional differences between the cell lines. These results provide an overview of the functional relationship among histone modifications and gene expression in human cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 425 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 17 | 4% |
| Germany | 5 | 1% |
| United Kingdom | 5 | 1% |
| France | 2 | <1% |
| Spain | 2 | <1% |
| Italy | 2 | <1% |
| Canada | 2 | <1% |
| Netherlands | 1 | <1% |
| Slovenia | 1 | <1% |
| Other | 5 | 1% |
| Unknown | 383 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 121 | 28% |
| Researcher | 98 | 23% |
| Student > Master | 51 | 12% |
| Student > Bachelor | 32 | 8% |
| Student > Doctoral Student | 24 | 6% |
| Other | 64 | 15% |
| Unknown | 35 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 207 | 49% |
| Biochemistry, Genetics and Molecular Biology | 89 | 21% |
| Medicine and Dentistry | 18 | 4% |
| Computer Science | 16 | 4% |
| Chemistry | 8 | 2% |
| Other | 43 | 10% |
| Unknown | 44 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2024.
All research outputs
#5,240,751
of 25,374,917 outputs
Outputs from Genome Research
#2,232
of 4,425 outputs
Outputs of similar age
#15,333
of 82,192 outputs
Outputs of similar age from Genome Research
#16
of 39 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,425 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.3. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,192 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.