| Title |
Stat3 is a positive regulator of gap junctional intercellular communication in cultured, human lung carcinoma cells
|
|---|---|
| Published in |
BMC Cancer, December 2012
|
| DOI | 10.1186/1471-2407-12-605 |
| Pubmed ID | |
| Authors |
Mulu Geletu, Rozanne Arulanandam, Samantha Greer, Aaron Trotman-Grant, Evangelia Tomai, Leda Raptis |
| Abstract |
Neoplastic transformation of cultured cells by a number of oncogenes such as src suppresses gap junctional, intercellular communication (GJIC); however, the role of Src and its effector Signal transducer and activator of transcription-3 (Stat3) upon GJIC in non small cell lung cancer (NSCLC) has not been defined. Immunohistochemical analysis revealed high Src activity in NSCLC biopsy samples compared to normal tissues. Here we explored the potential effect of Src and Stat3 upon GJIC, by assessing the levels of tyr418-phosphorylated Src and tyr705-phosphorylated Stat3, respectively, in a panel of NSCLC cell lines. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 7% |
| United States | 1 | 7% |
| Unknown | 13 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 40% |
| Professor > Associate Professor | 3 | 20% |
| Student > Bachelor | 2 | 13% |
| Other | 1 | 7% |
| Professor | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 1 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 33% |
| Biochemistry, Genetics and Molecular Biology | 4 | 27% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
| Medicine and Dentistry | 2 | 13% |
| Immunology and Microbiology | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 1 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2012.
All research outputs
#18,323,689
of 22,689,790 outputs
Outputs from BMC Cancer
#5,415
of 8,250 outputs
Outputs of similar age
#217,657
of 280,030 outputs
Outputs of similar age from BMC Cancer
#73
of 110 outputs
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