Title |
IL28B Single-Nucleotide Polymorphism rs12979860 Is Associated With Spontaneous HIV Control in White Subjects
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Published in |
Journal of Infectious Diseases, December 2012
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DOI | 10.1093/infdis/jis717 |
Pubmed ID | |
Authors |
Kawthar Machmach, Christina Abad-Molina, María C. Romero-Sánchez, María A. Abad, Sara Ferrando-Martínez, Miguel Genebat, Ildefonso Pulido, Pompeyo Viciana, María F. González-Escribano, Manuel Leal, Ezequiel Ruiz-Mateos |
Abstract |
The single-nucleotide polymorphism (SNP) rs12979860 near the IL28B gene has been associated with the spontaneous clearance of hepatitis C virus. We sought to determine whether this SNP could be associated with the spontaneous control of human immunodeficiency virus (HIV) infection. We studied the prevalence of the IL28B CC genotype among 53 white HIV controllers, compared with the prevalence among 389 HIV-infected noncontrollers. We found that the IL28B CC genotype was independently associated with spontaneous HIV control (odds ratio [OR], 2.669; P = .017), as were female sex (OR, 7.077; P ≤ .001) and the presence of HLA-B57 and/or B27 (OR, 3.080; P = .017). This result supports the idea that common host mechanisms are involved in the spontaneous control of these 2 chronic infections. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 1 | 2% |
France | 1 | 2% |
Italy | 1 | 2% |
Unknown | 44 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 17% |
Student > Ph. D. Student | 6 | 13% |
Student > Bachelor | 5 | 11% |
Student > Doctoral Student | 4 | 9% |
Other | 4 | 9% |
Other | 9 | 19% |
Unknown | 11 | 23% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 11 | 23% |
Medicine and Dentistry | 10 | 21% |
Biochemistry, Genetics and Molecular Biology | 5 | 11% |
Nursing and Health Professions | 3 | 6% |
Immunology and Microbiology | 2 | 4% |
Other | 3 | 6% |
Unknown | 13 | 28% |