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A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Overview of attention for article published in Human Molecular Genetics, October 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#29 of 8,179)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
14 news outlets
patent
12 patents

Citations

dimensions_citation
116 Dimensions

Readers on

mendeley
204 Mendeley
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Title
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
Published in
Human Molecular Genetics, October 2012
DOI 10.1093/hmg/dds425
Pubmed ID
Authors

A. Amin Al Olama, Z. Kote-Jarai, F. R. Schumacher, F. Wiklund, S. I. Berndt, S. Benlloch, G. G. Giles, G. Severi, D. E. Neal, F. C. Hamdy, J. L. Donovan, D. J. Hunter, B. E. Henderson, M. J. Thun, M. Gaziano, E. L. Giovannucci, A. Siddiq, R. C. Travis, D. G. Cox, F. Canzian, E. Riboli, T. J. Key, G. Andriole, D. Albanes, R. B. Hayes, J. Schleutker, A. Auvinen, T. L. J. Tammela, M. Weischer, J. L. Stanford, E. A. Ostrander, C. Cybulski, J. Lubinski, S. N. Thibodeau, D. J. Schaid, K. D. Sorensen, J. Batra, J. A. Clements, S. Chambers, J. Aitken, R. A. Gardiner, C. Maier, W. Vogel, T. Dork, H. Brenner, T. Habuchi, S. Ingles, E. M. John, J. L. Dickinson, L. Cannon-Albright, M. R. Teixeira, R. Kaneva, H.-W. Zhang, Y.-J. Lu, J. Y. Park, K. A. Cooney, K. R. Muir, D. A. Leongamornlert, E. Saunders, M. Tymrakiewicz, N. Mahmud, M. Guy, K. Govindasami, L. T. O'Brien, R. A. Wilkinson, A. L. Hall, E. J. Sawyer, T. Dadaev, J. Morrison, D. P. Dearnaley, A. Horwich, R. A. Huddart, V. S. Khoo, C. C. Parker, N. Van As, C. J. Woodhouse, A. Thompson, T. Dudderidge, C. Ogden, C. S. Cooper, A. Lophatonanon, M. C. Southey, J. L. Hopper, D. English, J. Virtamo, L. Le Marchand, D. Campa, R. Kaaks, S. Lindstrom, W. R. Diver, S. Gapstur, M. Yeager, A. Cox, M. C. Stern, R. Corral, M. Aly, W. Isaacs, J. Adolfsson, J. Xu, S. L. Zheng, T. Wahlfors, K. Taari, P. Kujala, P. Klarskov, B. G. Nordestgaard, M. A. Roder, R. Frikke-Schmidt, S. E. Bojesen, L. M. FitzGerald, S. Kolb, E. M. Kwon, D. M. Karyadi, T. F. Orntoft, M. Borre, A. Rinckleb, M. Luedeke, K. Herkommer, A. Meyer, J. Serth, J. R. Marthick, B. Patterson, D. Wokolorczyk, A. Spurdle, F. Lose, S. K. McDonnell, A. D. Joshi, A. Shahabi, P. Pinto, J. Santos, A. Ray, T. A. Sellers, H.-Y. Lin, R. A. Stephenson, C. Teerlink, H. Muller, D. Rothenbacher, N. Tsuchiya, S. Narita, G.-W. Cao, C. Slavov, V. Mitev, S. Chanock, H. Gronberg, C. A. Haiman, P. Kraft, D. F. Easton, R. A. Eeles

Abstract

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 204 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 1%
United States 2 <1%
Italy 2 <1%
Australia 1 <1%
Canada 1 <1%
Korea, Republic of 1 <1%
Denmark 1 <1%
Belgium 1 <1%
Japan 1 <1%
Other 1 <1%
Unknown 190 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 39 19%
Student > Ph. D. Student 32 16%
Other 23 11%
Professor 20 10%
Student > Master 13 6%
Other 43 21%
Unknown 34 17%
Readers by discipline Count As %
Medicine and Dentistry 54 26%
Agricultural and Biological Sciences 38 19%
Biochemistry, Genetics and Molecular Biology 31 15%
Computer Science 11 5%
Social Sciences 3 1%
Other 26 13%
Unknown 41 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 124. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2022.
All research outputs
#313,311
of 24,312,464 outputs
Outputs from Human Molecular Genetics
#29
of 8,179 outputs
Outputs of similar age
#1,576
of 176,171 outputs
Outputs of similar age from Human Molecular Genetics
#2
of 78 outputs
Altmetric has tracked 24,312,464 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,179 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,171 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.