| Title |
Pain in long-term breast cancer survivors: the role of body mass index, physical activity, and sedentary behavior
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, December 2012
|
| DOI | 10.1007/s10549-012-2335-7 |
| Pubmed ID | |
| Authors |
Laura P. Forsythe, Catherine M. Alfano, Stephanie M. George, Anne McTiernan, Kathy B. Baumgartner, Leslie Bernstein, Rachel Ballard-Barbash |
| Abstract |
Although pain is common among post-treatment breast cancer survivors, studies that are longitudinal, identify a case definition of clinically meaningful pain, or examine factors contributing to pain in survivors are limited. This study describes longitudinal patterns of pain in long-term breast cancer survivors, evaluating associations of body mass index (BMI), physical activity, sedentary behavior with mean pain severity and above-average pain. Women newly diagnosed with stages 0-IIIA breast cancer (N = 1183) were assessed, on average, 6 months (demographic/clinical characteristics), 30 months (demographics), 40 months (demographics, pain), 5 years (BMI, physical activity, and sedentary behavior), and 10 years (demographics, pain, BMI, physical activity, and sedentary behavior) post-diagnosis. This analysis includes survivors who completed pain assessments 40 months post-diagnosis (N = 801), 10 years post-diagnosis (N = 563), or both (N = 522). Above-average pain was defined by SF-36 bodily pain scores ≥1/2 standard deviation worse than age-specific population norms. We used multiple regression models to test unique associations of BMI, physical activity, and sedentary behavior with pain adjusting for demographic and clinical factors. The proportion of survivors reporting above-average pain was higher at 10 years than at 40 months (32.3 vs. 27.8 %, p < 0.05). Approximately one-quarter of survivors reported improved pain, while 9.0 % maintained above-average pain and 33.1 % reported worsened pain. Cross-sectionally at 10 years, overweight and obese survivors reported higher pain than normal-weight survivors and women meeting physical activity guidelines were less likely to report above-average pain than survivors not meeting these guidelines (p < 0.05). Longitudinally, weight gain (>5 %) was positively associated, while meeting physical activity guidelines was inversely associated, with above-average pain (OR, 95 % CI = 1.76, 1.03-3.01 and 0.40, 0.20-0.84, respectively) (p < 0.05). Weight gain and lack of physical activity place breast cancer survivors at risk for pain long after treatment ends. Weight control and exercise interventions should be tested for effects on long-term pain in these women. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 134 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 28 | 21% |
| Student > Bachelor | 17 | 13% |
| Student > Ph. D. Student | 13 | 10% |
| Researcher | 11 | 8% |
| Other | 9 | 7% |
| Other | 26 | 19% |
| Unknown | 32 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 25% |
| Nursing and Health Professions | 25 | 18% |
| Sports and Recreations | 10 | 7% |
| Social Sciences | 7 | 5% |
| Agricultural and Biological Sciences | 5 | 4% |
| Other | 13 | 10% |
| Unknown | 42 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2013.
All research outputs
#14,854,023
of 24,059,832 outputs
Outputs from Breast Cancer Research and Treatment
#3,152
of 4,819 outputs
Outputs of similar age
#171,307
of 286,359 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#46
of 64 outputs
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