Title |
Measurement of functional microcirculatory geometry and velocity distributions using automated image analysis
|
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Published in |
Medical & Biological Engineering & Computing, April 2008
|
DOI | 10.1007/s11517-008-0349-4 |
Pubmed ID | |
Authors |
J. G. G. Dobbe, G. J. Streekstra, B. Atasever, R. van Zijderveld, C. Ince |
Abstract |
This study describes a new method for analyzing microcirculatory videos. It introduces algorithms for quantitative assessment of vessel length, diameter, the functional microcirculatory density distribution and red blood-cell (RBC) velocity in individual vessels as well as its distribution. The technique was validated and compared to commercial software. The method was applied to the sublingual microcirculation in a healthy volunteer and in a patient during cardiac surgery. Analysis time was reduced from hours to minutes compared to previous methods requiring manual vessel identification. Vessel diameter was detected with high accuracy (>80%, d > 3 pixels). Capillary length was estimated within 5 pixels accuracy. Velocity estimation was very accurate (>95%) in the range [2.5, 1,000] pixels/s. RBC velocity was reduced by 70% during the first 10 s of cardiac luxation. The present method has been shown to be fast and accurate and provides increased insight into the functional properties of the microcirculation. |
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Geographical breakdown
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Japan | 1 | 1% |
Unknown | 94 | 96% |
Demographic breakdown
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Student > Ph. D. Student | 18 | 18% |
Researcher | 17 | 17% |
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Professor > Associate Professor | 9 | 9% |
Student > Bachelor | 8 | 8% |
Other | 20 | 20% |
Unknown | 11 | 11% |
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