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Is the haematopoietic effect of testosterone mediated by erythropoietin? The results of a clinical trial in older men

Overview of attention for article published in Andrology, October 2012
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Title
Is the haematopoietic effect of testosterone mediated by erythropoietin? The results of a clinical trial in older men
Published in
Andrology, October 2012
DOI 10.1111/j.2047-2927.2012.00009.x
Pubmed ID
Authors

M. Maggio, P. J. Snyder, G. P. Ceda, Y. Milaneschi, M. Luci, C. Cattabiani, S. Masoni, A. Vignali, R. Volpi, F. Lauretani, H. Peachey, G. Valenti, A. R. Cappola, D. Longo, L. Ferrucci

Abstract

The stimulatory effects of testosterone on erythropoiesis are very well known, but the mechanisms underlying the erythropoietic action of testosterone are still poorly understood, although erythropoietin has long been considered a potential mediator. A total of 108 healthy men >65 years old with serum testosterone concentration <475 ng/dL were recruited by direct mailings to alumni of the University of Pennsylvania and Temple University, and randomized to receive a 60-cm(2) testosterone or placebo patch for 36 months. Ninety-six subjects completed the trial. We used information and stored serum specimens from this trial to test the hypothesis that increasing testosterone increases haemoglobin by stimulating erythropoietin production. We used information of 67 men, 43 in the testosterone group and 24 in the placebo group who had banked specimens available for assays of testosterone, haemoglobin and erythropoietin at baseline and after 36 months. The original randomized clinical study was primarily designed to verify the effects of testosterone on bone mineral density. The primary outcome of this report was to investigate whether or not transdermal testosterone increases haemoglobin by increasing erythropoietin levels. The mean age ± SD of the 67 subjects at baseline was 71.8 ± 4.9 years. Testosterone replacement therapy for 36 months, as compared with placebo, induced a significant increase in haemoglobin (0.86 ± 0.31 g/dL, p = 0.01), but no change in erythropoietin levels (-0.24 ± 2.16 mIU/mL, p = 0.91). Included time-varying measure of erythropoietin did not significantly account for the effect of testosterone on haemoglobin (Treatment-by-time: β = 0.93, SE = 0.33, p = 0.01). No serious adverse effect was observed. Transdermal testosterone treatment of older men for 36 months significantly increased haemoglobin, but not erythropoietin levels. The haematopoietic effect of testosterone does not appear to be mediated by stimulation of erythropoietin production.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Professor 6 19%
Researcher 5 16%
Student > Ph. D. Student 4 13%
Other 3 9%
Student > Bachelor 2 6%
Other 4 13%
Unknown 8 25%
Readers by discipline Count As %
Medicine and Dentistry 10 31%
Agricultural and Biological Sciences 3 9%
Biochemistry, Genetics and Molecular Biology 3 9%
Sports and Recreations 2 6%
Nursing and Health Professions 1 3%
Other 3 9%
Unknown 10 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2018.
All research outputs
#15,588,886
of 24,704,144 outputs
Outputs from Andrology
#504
of 1,009 outputs
Outputs of similar age
#106,254
of 179,037 outputs
Outputs of similar age from Andrology
#6
of 14 outputs
Altmetric has tracked 24,704,144 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,009 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.1. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,037 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.