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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

Overview of attention for article published in Nature Genetics, December 2012
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Citations

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679 Dimensions

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444 Mendeley
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5 CiteULike
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Title
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Published in
Nature Genetics, December 2012
DOI 10.1038/ng.2500
Pubmed ID
Authors

Anna Köttgen, Eva Albrecht, Alexander Teumer, Veronique Vitart, Jan Krumsiek, Claudia Hundertmark, Giorgio Pistis, Daniela Ruggiero, Conall M O'Seaghdha, Toomas Haller, Qiong Yang, Toshiko Tanaka, Andrew D Johnson, Zoltán Kutalik, Albert V Smith, Julia Shi, Maksim Struchalin, Rita P S Middelberg, Morris J Brown, Angelo L Gaffo, Nicola Pirastu, Guo Li, Caroline Hayward, Tatijana Zemunik, Jennifer Huffman, Loic Yengo, Jing Hua Zhao, Ayse Demirkan, Mary F Feitosa, Xuan Liu, Giovanni Malerba, Lorna M Lopez, Pim van der Harst, Xinzhong Li, Marcus E Kleber, Andrew A Hicks, Ilja M Nolte, Asa Johansson, Federico Murgia, Sarah H Wild, Stephan J L Bakker, John F Peden, Abbas Dehghan, Maristella Steri, Albert Tenesa, Vasiliki Lagou, Perttu Salo, Massimo Mangino, Lynda M Rose, Terho Lehtimäki, Owen M Woodward, Yukinori Okada, Adrienne Tin, Christian Müller, Christopher Oldmeadow, Margus Putku, Darina Czamara, Peter Kraft, Laura Frogheri, Gian Andri Thun, Anne Grotevendt, Gauti Kjartan Gislason, Tamara B Harris, Lenore J Launer, Patrick McArdle, Alan R Shuldiner, Eric Boerwinkle, Josef Coresh, Helena Schmidt, Michael Schallert, Nicholas G Martin, Grant W Montgomery, Michiaki Kubo, Yusuke Nakamura, Toshihiro Tanaka, Patricia B Munroe, Nilesh J Samani, David R Jacobs, Kiang Liu, Pio D'Adamo, Sheila Ulivi, Jerome I Rotter, Bruce M Psaty, Peter Vollenweider, Gerard Waeber, Susan Campbell, Olivier Devuyst, Pau Navarro, Ivana Kolcic, Nicholas Hastie, Beverley Balkau, Philippe Froguel, Tõnu Esko, Andres Salumets, Kay Tee Khaw, Claudia Langenberg, Nicholas J Wareham, Aaron Isaacs, Aldi Kraja, Qunyuan Zhang, Philipp S Wild, Rodney J Scott, Elizabeth G Holliday, Elin Org, Margus Viigimaa, Stefania Bandinelli, Jeffrey E Metter, Antonio Lupo, Elisabetta Trabetti, Rossella Sorice, Angela Döring, Eva Lattka, Konstantin Strauch, Fabian Theis, Melanie Waldenberger, H-Erich Wichmann, Gail Davies, Alan J Gow, Marcel Bruinenberg, Ronald P Stolk, Jaspal S Kooner, Weihua Zhang, Bernhard R Winkelmann, Bernhard O Boehm, Susanne Lucae, Brenda W Penninx, Johannes H Smit, Gary Curhan, Poorva Mudgal, Robert M Plenge, Laura Portas, Ivana Persico, Mirna Kirin, James F Wilson, Irene Mateo Leach, Wiek H van Gilst, Anuj Goel, Halit Ongen, Albert Hofman, Fernando Rivadeneira, Andre G Uitterlinden, Medea Imboden, Arnold von Eckardstein, Francesco Cucca, Ramaiah Nagaraja, Maria Grazia Piras, Matthias Nauck, Claudia Schurmann, Kathrin Budde, Florian Ernst, Susan M Farrington, Evropi Theodoratou, Inga Prokopenko, Michael Stumvoll, Antti Jula, Markus Perola, Veikko Salomaa, So-Youn Shin, Tim D Spector, Cinzia Sala, Paul M Ridker, Mika Kähönen, Jorma Viikari, Christian Hengstenberg, Christopher P Nelson, James F Meschia, Michael A Nalls, Pankaj Sharma, Andrew B Singleton, Naoyuki Kamatani, Tanja Zeller, Michel Burnier, John Attia, Maris Laan, Norman Klopp, Hans L Hillege, Stefan Kloiber, Hyon Choi, Mario Pirastu, Silvia Tore, Nicole M Probst-Hensch, Henry Völzke, Vilmundur Gudnason, Afshin Parsa, Reinhold Schmidt, John B Whitfield, Myriam Fornage, Paolo Gasparini, David S Siscovick, Ozren Polašek, Harry Campbell, Igor Rudan, Nabila Bouatia-Naji, Andres Metspalu, Ruth J F Loos, Cornelia M van Duijn, Ingrid B Borecki, Luigi Ferrucci, Giovanni Gambaro, Ian J Deary, Bruce H R Wolffenbuttel, John C Chambers, Winfried März, Peter P Pramstaller, Harold Snieder, Ulf Gyllensten, Alan F Wright, Gerjan Navis, Hugh Watkins, Jacqueline C M Witteman, Serena Sanna, Sabine Schipf, Malcolm G Dunlop, Anke Tönjes, Samuli Ripatti, Nicole Soranzo, Daniela Toniolo, Daniel I Chasman, Olli Raitakari, W H Linda Kao, Marina Ciullo, Caroline S Fox, Mark Caulfield, Murielle Bochud, Christian Gieger

Abstract

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 444 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 5 1%
United States 3 <1%
Japan 2 <1%
Portugal 1 <1%
Canada 1 <1%
Finland 1 <1%
Hungary 1 <1%
Mexico 1 <1%
Unknown 429 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 85 19%
Student > Ph. D. Student 70 16%
Student > Master 49 11%
Professor 38 9%
Student > Bachelor 37 8%
Other 92 21%
Unknown 73 16%
Readers by discipline Count As %
Medicine and Dentistry 103 23%
Agricultural and Biological Sciences 99 22%
Biochemistry, Genetics and Molecular Biology 81 18%
Pharmacology, Toxicology and Pharmaceutical Science 9 2%
Computer Science 8 2%
Other 53 12%
Unknown 91 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 49. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2022.
All research outputs
#755,644
of 23,504,694 outputs
Outputs from Nature Genetics
#1,417
of 7,286 outputs
Outputs of similar age
#6,116
of 284,431 outputs
Outputs of similar age from Nature Genetics
#9
of 84 outputs
Altmetric has tracked 23,504,694 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,286 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.7. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,431 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.