| Title |
Saturated Fatty Acids and Risk of Coronary Heart Disease: Modulation by Replacement Nutrients
|
|---|---|
| Published in |
Current Atherosclerosis Reports, August 2010
|
| DOI | 10.1007/s11883-010-0131-6 |
| Pubmed ID | |
| Authors |
Patty W. Siri-Tarino, Qi Sun, Frank B. Hu, Ronald M. Krauss |
| Abstract |
Despite the well-established observation that substitution of saturated fats for carbohydrates or unsaturated fats increases low-density lipoprotein (LDL) cholesterol in humans and animal models, the relationship of saturated fat intake to risk for atherosclerotic cardiovascular disease in humans remains controversial. A critical question is what macronutrient should be used to replace saturated fat. Substituting polyunsaturated fat for saturated fat reduces LDL cholesterol and the total cholesterol to high-density lipoprotein cholesterol ratio. However, replacement of saturated fat by carbohydrates, particularly refined carbohydrates and added sugars, increases levels of triglyceride and small LDL particles and reduces high-density lipoprotein cholesterol, effects that are of particular concern in the context of the increased prevalence of obesity and insulin resistance. Epidemiologic studies and randomized clinical trials have provided consistent evidence that replacing saturated fat with polyunsaturated fat, but not carbohydrates, is beneficial for coronary heart disease. Therefore, dietary recommendations should emphasize substitution of polyunsaturated fat and minimally processed grains for saturated fat. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 16% |
| United States | 3 | 16% |
| Antarctica | 1 | 5% |
| India | 1 | 5% |
| Norway | 1 | 5% |
| Saudi Arabia | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 8 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 68% |
| Scientists | 4 | 21% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 679 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| United Kingdom | 3 | <1% |
| Netherlands | 2 | <1% |
| Italy | 1 | <1% |
| Australia | 1 | <1% |
| Sweden | 1 | <1% |
| Ecuador | 1 | <1% |
| Indonesia | 1 | <1% |
| Canada | 1 | <1% |
| Other | 6 | <1% |
| Unknown | 658 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 157 | 23% |
| Student > Master | 100 | 15% |
| Student > Ph. D. Student | 64 | 9% |
| Researcher | 50 | 7% |
| Student > Postgraduate | 27 | 4% |
| Other | 96 | 14% |
| Unknown | 185 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 119 | 18% |
| Agricultural and Biological Sciences | 99 | 15% |
| Nursing and Health Professions | 64 | 9% |
| Biochemistry, Genetics and Molecular Biology | 59 | 9% |
| Chemistry | 17 | 3% |
| Other | 117 | 17% |
| Unknown | 204 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 309. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2024.
All research outputs
#112,892
of 25,728,855 outputs
Outputs from Current Atherosclerosis Reports
#6
of 871 outputs
Outputs of similar age
#226
of 105,162 outputs
Outputs of similar age from Current Atherosclerosis Reports
#1
of 11 outputs
Altmetric has tracked 25,728,855 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 871 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,162 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.