Title |
Microalgal compounds modulate carcinogenesis in the gastrointestinal tract
|
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Published in |
Trends in Biotechnology, December 2012
|
DOI | 10.1016/j.tibtech.2012.11.004 |
Pubmed ID | |
Authors |
Helena M. Amaro, Rita Barros, A. Catarina Guedes, I. Sousa-Pinto, F. Xavier Malcata |
Abstract |
Gastrointestinal cancers rank second in overall cancer-related deaths. Carotenoids, sulfated polysaccharides, and polyunsaturated fatty acids (PUFAs) from microalgae exhibit cancer chemopreventive features at different stages of carcinogenesis. For instance, sulfated polysaccharides bear a prophylactic potential via blocking adhesion of pathogens to the gastric surface, whereas carotenoids are effective against Helicobacter pylori infection. This effect is notable because H. pylori has been targeted as the primary cause of gastric cancer. Recent results on antitumor and antibacterial compounds synthesized by microalgae are reviewed here, with an emphasis on their impact upon H. pylori infection and derived pathologies accompanying the progression of gastric carcinogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 43% |
Venezuela, Bolivarian Republic of | 1 | 14% |
India | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 57% |
Scientists | 2 | 29% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
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Portugal | 1 | 1% |
Turkey | 1 | 1% |
Italy | 1 | 1% |
India | 1 | 1% |
United Kingdom | 1 | 1% |
Nigeria | 1 | 1% |
Unknown | 90 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 20 | 21% |
Student > Ph. D. Student | 12 | 13% |
Researcher | 11 | 11% |
Student > Bachelor | 9 | 9% |
Other | 8 | 8% |
Other | 21 | 22% |
Unknown | 15 | 16% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 35 | 36% |
Biochemistry, Genetics and Molecular Biology | 9 | 9% |
Chemical Engineering | 6 | 6% |
Chemistry | 5 | 5% |
Immunology and Microbiology | 4 | 4% |
Other | 19 | 20% |
Unknown | 18 | 19% |