| Title |
Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months’ consumption of a combination of bioactive food ingredients in overweight subjects
|
|---|---|
| Published in |
Endocrine, December 2012
|
| DOI | 10.1007/s12020-012-9863-0 |
| Pubmed ID | |
| Authors |
Mariangela Rondanelli, Annalisa Opizzi, Simone Perna, Milena Faliva, Sebastiano Bruno Solerte, Marisa Fioravanti, Catherine Klersy, Cava Edda, Paolini Maddalena, Scavone Luciano, Ceccarelli Paola, Castellaneta Emanuela, Savina Claudia, Lorenzo Maria Donini |
| Abstract |
This randomized, double blind, placebo-controlled, 8 week trial assessed the efficacy on metabolic changes produced by a consumption of a combination of bioactive food ingredients (epigallocatechin gallate, capsaicins, piperine and L-carnitine) versus a placebo, as part of a therapeutic 'lifestyle change' diet, in 86 overweight subjects. Forty-one patients (2/14 F/M; age 43.7 ± 8.5; BMI 30.3 ± 3.5 kg/m(2)) were randomized to the supplemented group and 45 (29/16; age 40.7 ± 10.2; BMI 30.0 ± 2.7) to the control group. We observed that consumption of the dietary supplement was associated with a significantly greater decrease in insulin resistance, assessed by homostasis model assessment (p < 0.001), leptin/adiponectin ratio (p < 0.04), respiratory quotient (p < 0.008). LDL-cholesterol levels (p < 0.01). Moreover, statistically significant differences were recorded between the two groups in relation to urinary norepinephrine levels (p < 0.001). Leptin, ghrelin, C-reactive protein decreased and resting energy expenditure increased significantly in the supplemented group (p < 0.05, 0.03, 0.02 and 0,02 respectively), but not in the placebo group; adiponectin decreased significantly in the placebo group (0.001) but not in the supplemented group, although no statistical significance between the groups was elicited. BMI, fat mass (assessed by DXA) and vascular endothelial growth factor significantly decreased, whilst the resting energy expenditure/free fat mass significantly increased in both groups. In general, a greater change was recorded in the supplemented group compared to the placebo, although no statistically significant difference between the two groups was recorded. These results suggest that the combination of bioactive food ingredients studied might be useful for the treatment of obesity-related inflammatory metabolic dysfunctions. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | <1% |
| Unknown | 133 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 17% |
| Student > Ph. D. Student | 16 | 12% |
| Student > Master | 13 | 10% |
| Researcher | 10 | 7% |
| Student > Doctoral Student | 6 | 4% |
| Other | 19 | 14% |
| Unknown | 47 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 16% |
| Nursing and Health Professions | 14 | 10% |
| Agricultural and Biological Sciences | 13 | 10% |
| Biochemistry, Genetics and Molecular Biology | 8 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Other | 16 | 12% |
| Unknown | 56 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2022.
All research outputs
#1,053,799
of 23,213,531 outputs
Outputs from Endocrine
#43
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Outputs of similar age
#9,372
of 282,587 outputs
Outputs of similar age from Endocrine
#1
of 17 outputs
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