| Title |
A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity
|
|---|---|
| Published in |
Rheumatology International, December 2011
|
| DOI | 10.1007/s00296-011-2263-6 |
| Pubmed ID | |
| Authors |
Philip G. Conaghan |
| Abstract |
Non-steroidal anti-inflammatory drugs (NSAIDs) represent a diverse class of drugs and are among the most commonly used analgesics for arthritic pain worldwide, though long-term use is associated with a spectrum of adverse effects. The introduction of cyclooxygenase-2-selective NSAIDs early in the last decade offered an alternative to traditional NSAIDs with similar efficacy and improved gastrointestinal tolerability; however, emerging concerns about cardiovascular safety resulted in the withdrawal of two agents (rofecoxib and valdecoxib) in the mid-2000s and, subsequently, in an overall reduction in NSAID use. It is now understood that all NSAIDs are associated with some varying degree of gastrointestinal and cardiovascular risk. Guidelines still recommend their use, but little is known of how patients use these agents. While strategies and guidelines aimed at reducing NSAID-associated complications exist, there is a need for evidence-based algorithms combining cardiovascular and gastrointestinal factors that can be used to aid treatment decisions at an individual patient level. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Bulgaria | 2 | 29% |
| Turkey | 1 | 14% |
| United Kingdom | 1 | 14% |
| Italy | 1 | 14% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 473 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | <1% |
| Ghana | 1 | <1% |
| Malaysia | 1 | <1% |
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 467 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 75 | 16% |
| Student > Master | 68 | 14% |
| Student > Ph. D. Student | 40 | 8% |
| Researcher | 37 | 8% |
| Student > Postgraduate | 26 | 5% |
| Other | 84 | 18% |
| Unknown | 143 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 117 | 25% |
| Pharmacology, Toxicology and Pharmaceutical Science | 59 | 12% |
| Agricultural and Biological Sciences | 31 | 7% |
| Chemistry | 24 | 5% |
| Biochemistry, Genetics and Molecular Biology | 23 | 5% |
| Other | 55 | 12% |
| Unknown | 164 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2024.
All research outputs
#1,065,771
of 25,743,152 outputs
Outputs from Rheumatology International
#43
of 2,514 outputs
Outputs of similar age
#6,221
of 250,631 outputs
Outputs of similar age from Rheumatology International
#2
of 50 outputs
Altmetric has tracked 25,743,152 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,514 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,631 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.