| Title |
Gastrointestinal manifestations in Parkinson’s disease: prevalence and occurrence before motor symptoms
|
|---|---|
| Published in |
Journal of Neurology, December 2012
|
| DOI | 10.1007/s00415-012-6801-2 |
| Pubmed ID | |
| Authors |
Maria G. Cersosimo, Gabriela B. Raina, Cristina Pecci, Alejandro Pellene, Cristian R. Calandra, Cristiam Gutiérrez, Federico E. Micheli, Eduardo E. Benarroch |
| Abstract |
To assess the prevalence of gastrointestinal symptoms (GIS) in Parkinson's disease (PD) compared to control subjects and their timing of appearance in relationship to the onset of motor symptoms. There is a rostrocaudal gradient of alpha-synuclein (α-SYN) neuropathology in the enteric nervous system at early stages of PD with higher burden in the upper than the lower gut. However, only constipation has been recognized as a premotor gastrointestinal manifestation of PD. 129 PD patients and 120 controls underwent a structured questionnaire to assess the presence of GIS and, in PD patients, the time of their appearance respect to the onset of motor manifestations. GIS significantly more prevalent in PD patients were dry mouth, drooling, dysphagia, constipation and defecatory dysfunction. Constipation and defecatory dysfunction preceded motor manifestations. Whereas gastroparesis symptoms preceded motor manifestations, their prevalence was not significantly different from controls. Despite evidence of a higher α-SYN burden in the upper gut, only constipation and defecatory dysfunction were prominent premotor GIS of PD. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 1 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 222 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 219 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 35 | 16% |
| Student > Bachelor | 30 | 14% |
| Student > Ph. D. Student | 23 | 10% |
| Researcher | 21 | 9% |
| Student > Doctoral Student | 17 | 8% |
| Other | 30 | 14% |
| Unknown | 66 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 52 | 23% |
| Neuroscience | 29 | 13% |
| Agricultural and Biological Sciences | 20 | 9% |
| Biochemistry, Genetics and Molecular Biology | 19 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
| Other | 22 | 10% |
| Unknown | 75 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2013.
All research outputs
#8,088,427
of 24,293,076 outputs
Outputs from Journal of Neurology
#1,963
of 4,755 outputs
Outputs of similar age
#87,201
of 288,564 outputs
Outputs of similar age from Journal of Neurology
#23
of 41 outputs
Altmetric has tracked 24,293,076 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 4,755 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,564 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.