| Title |
Bisphosphonate Drug Holiday: Choosing Appropriate Candidates
|
|---|---|
| Published in |
Current Osteoporosis Reports, January 2013
|
| DOI | 10.1007/s11914-012-0129-9 |
| Pubmed ID | |
| Authors |
Cynthia Ro, Odelia Cooper |
| Abstract |
Osteoporosis related fractures contribute to morbidity and mortality in U.S. patients, placing a heavy financial burden on society. Randomized clinical trials involving over 30,000 subjects have established bisphosphonates' efficacy in reducing the incidence of fragility fractures. However, as bisphosphonates are retained for years in the skeleton, reports of adverse events from prolonged use are surfacing in the literature, namely, esophageal cancer, atrial fibrillation, osteonecrosis of the jaw, and atypical fracture development. The concept of a drug holiday has been proposed to potentially reduce incidence of these adverse events. This review will highlight the benefits and risks of bisphosphonate therapy and discuss the extension data available from the bisphosphonate trials. As randomized clinical trial evidence is not yet available on who may qualify for drug holiday, this review will provide suggestions for clinicians on identification of possible candidates and monitoring during a bisphosphonate drug holiday. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 2 | 13% |
| United Kingdom | 1 | 7% |
| Colombia | 1 | 7% |
| Mexico | 1 | 7% |
| Nepal | 1 | 7% |
| Canada | 1 | 7% |
| United States | 1 | 7% |
| Unknown | 7 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 87% |
| Scientists | 1 | 7% |
| Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 73 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 17% |
| Student > Ph. D. Student | 10 | 13% |
| Student > Postgraduate | 9 | 12% |
| Student > Bachelor | 8 | 11% |
| Professor | 5 | 7% |
| Other | 13 | 17% |
| Unknown | 17 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 57% |
| Agricultural and Biological Sciences | 2 | 3% |
| Nursing and Health Professions | 2 | 3% |
| Social Sciences | 2 | 3% |
| Linguistics | 1 | 1% |
| Other | 5 | 7% |
| Unknown | 20 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2023.
All research outputs
#4,281,360
of 25,654,806 outputs
Outputs from Current Osteoporosis Reports
#92
of 620 outputs
Outputs of similar age
#41,552
of 291,465 outputs
Outputs of similar age from Current Osteoporosis Reports
#1
of 3 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 620 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,465 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them