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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Common variants in the HLA-DRB1–HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis
|
|---|---|
| Published in |
Nature Genetics, January 2013
|
| DOI | 10.1038/ng.2518 |
| Pubmed ID | |
| Authors |
Michaela Fakiola, Amy Strange, Heather J Cordell, E Nancy Miller, Matti Pirinen, Zhan Su, Anshuman Mishra, Sanjana Mehrotra, Gloria R Monteiro, Gavin Band, Céline Bellenguez, Serge Dronov, Sarah Edkins, Colin Freeman, Eleni Giannoulatou, Emma Gray, Sarah E Hunt, Henio G Lacerda, Cordelia Langford, Richard Pearson, Núbia N Pontes, Madhukar Rai, Shri P Singh, Linda Smith, Olivia Sousa, Damjan Vukcevic, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Audrey Duncanson, Janusz Jankowski, Hugh S Markus, Christopher G Mathew, Colin N A Palmer, Robert Plomin, Anna Rautanen, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas W Wood, Mary E Wilson, Panos Deloukas, Leena Peltonen, Frank Christiansen, Campbell Witt, Selma M B Jeronimo, Shyam Sundar, Chris C A Spencer, Jenefer M Blackwell, Peter Donnelly |
| Abstract |
To identify susceptibility loci for visceral leishmaniasis, we undertook genome-wide association studies in two populations: 989 cases and 1,089 controls from India and 357 cases in 308 Brazilian families (1,970 individuals). The HLA-DRB1-HLA-DQA1 locus was the only region to show strong evidence of association in both populations. Replication at this region was undertaken in a second Indian population comprising 941 cases and 990 controls, and combined analysis across the three cohorts for rs9271858 at this locus showed P(combined) = 2.76 × 10(-17) and odds ratio (OR) = 1.41, 95% confidence interval (CI) = 1.30-1.52. A conditional analysis provided evidence for multiple associations within the HLA-DRB1-HLA-DQA1 region, and a model in which risk differed between three groups of haplotypes better explained the signal and was significant in the Indian discovery and replication cohorts. In conclusion, the HLA-DRB1-HLA-DQA1 HLA class II region contributes to visceral leishmaniasis susceptibility in India and Brazil, suggesting shared genetic risk factors for visceral leishmaniasis that cross the epidemiological divides of geography and parasite species. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Finland | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 125 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 24% |
| Student > Ph. D. Student | 21 | 16% |
| Student > Master | 16 | 12% |
| Student > Bachelor | 13 | 10% |
| Professor | 11 | 8% |
| Other | 22 | 17% |
| Unknown | 16 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 34% |
| Medicine and Dentistry | 20 | 15% |
| Biochemistry, Genetics and Molecular Biology | 18 | 14% |
| Immunology and Microbiology | 14 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 11 | 8% |
| Unknown | 20 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2023.
All research outputs
#2,463,100
of 23,505,669 outputs
Outputs from Nature Genetics
#2,960
of 7,287 outputs
Outputs of similar age
#25,419
of 284,942 outputs
Outputs of similar age from Nature Genetics
#38
of 78 outputs
Altmetric has tracked 23,505,669 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,287 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.8. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,942 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.