| Title |
Synaptic Vesicle Exocytosis in Hippocampal Synaptosomes Correlates Directly with Total Mitochondrial Volume
|
|---|---|
| Published in |
Journal of Molecular Neuroscience, July 2012
|
| DOI | 10.1007/s12031-012-9848-8 |
| Pubmed ID | |
| Authors |
Maxim V. Ivannikov, Mutsuyuki Sugimori, Rodolfo R. Llinás |
| Abstract |
Synaptic plasticity in many regions of the central nervous system leads to the continuous adjustment of synaptic strength, which is essential for learning and memory. In this study, we show by visualizing synaptic vesicle release in mouse hippocampal synaptosomes that presynaptic mitochondria and, specifically, their capacities for ATP production are essential determinants of synaptic vesicle exocytosis and its magnitude. Total internal reflection microscopy of FM1-43 loaded hippocampal synaptosomes showed that inhibition of mitochondrial oxidative phosphorylation reduces evoked synaptic release. This reduction was accompanied by a substantial drop in synaptosomal ATP levels. However, cytosolic calcium influx was not affected. Structural characterization of stimulated hippocampal synaptosomes revealed that higher total presynaptic mitochondrial volumes were consistently associated with higher levels of exocytosis. Thus, synaptic vesicle release is linked to the presynaptic ability to regenerate ATP, which itself is a utility of mitochondrial density and activity. |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 1% |
| Portugal | 1 | 1% |
| Unknown | 69 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 23% |
| Student > Ph. D. Student | 14 | 20% |
| Student > Master | 13 | 18% |
| Student > Bachelor | 8 | 11% |
| Student > Doctoral Student | 5 | 7% |
| Other | 7 | 10% |
| Unknown | 8 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 27% |
| Agricultural and Biological Sciences | 18 | 25% |
| Biochemistry, Genetics and Molecular Biology | 13 | 18% |
| Medicine and Dentistry | 5 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 10 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2022.
All research outputs
#7,959,659
of 25,373,627 outputs
Outputs from Journal of Molecular Neuroscience
#448
of 1,643 outputs
Outputs of similar age
#54,690
of 177,935 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#6
of 24 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,643 research outputs from this source. They receive a mean Attention Score of 3.9. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,935 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.