| Title |
Oxytocin in survivors of childhood-onset craniopharyngioma
|
|---|---|
| Published in |
Endocrine, September 2016
|
| DOI | 10.1007/s12020-016-1084-5 |
| Pubmed ID | |
| Authors |
Anna M. M. Daubenbüchel, Anika Hoffmann, Maria Eveslage, Jale Özyurt, Kristin Lohle, Julia Reichel, Christiane M. Thiel, Henri Martens, Vincent Geenen, Hermann L. Müller |
| Abstract |
Quality of survival of childhood-onset craniopharyngioma patients is frequently impaired by hypothalamic involvement or surgical lesions sequelae such as obesity and neuropsychological deficits. Oxytocin, a peptide hormone produced in the hypothalamus and secreted by posterior pituitary gland, plays a major role in regulation of behavior and body composition. In a cross-sectional study, oxytocin saliva concentrations were analyzed in 34 long-term craniopharyngioma survivors with and without hypothalamic involvement or treatment-related damage, recruited in the German Childhood Craniopharyngioma Registry, and in 73 healthy controls, attending the Craniopharyngioma Support Group Meeting 2014. Oxytocin was measured in saliva of craniopharyngioma patients and controls before and after standardized breakfast and associations with gender, body mass index, hypothalamic involvement, diabetes insipidus, and irradiation were analyzed. Patients with preoperative hypothalamic involvement showed similar oxytocin levels compared to patients without hypothalamic involvement and controls. However, patients with surgical hypothalamic lesions grade 1 (anterior hypothalamic area) presented with lower levels (p = 0.017) of oxytocin under fasting condition compared to patients with surgical lesion of posterior hypothalamic areas (grade 2) and patients without hypothalamic lesions (grade 0). Craniopharyngioma patients' changes in oxytocin levels before and after breakfast correlated (p = 0.02) with their body mass index. Craniopharyngioma patients continue to secrete oxytocin, especially when anterior hypothalamic areas are not involved or damaged, but oxytocin shows less variation due to nutrition. Oxytocin supplementation should be explored as a therapeutic option in craniopharyngioma patients with hypothalamic obesity and/or behavioral pathologies due to lesions of specific anterior hypothalamic areas. KRANIOPHARYNGEOM 2000/2007(NCT00258453; NCT01272622). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 70 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 19% |
| Student > Ph. D. Student | 12 | 17% |
| Student > Postgraduate | 5 | 7% |
| Student > Master | 5 | 7% |
| Researcher | 4 | 6% |
| Other | 13 | 19% |
| Unknown | 18 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 27% |
| Nursing and Health Professions | 6 | 9% |
| Neuroscience | 6 | 9% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Psychology | 4 | 6% |
| Other | 10 | 14% |
| Unknown | 20 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2016.
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#22,759,452
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Outputs from Endocrine
#1,584
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Outputs of similar age
#308,503
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Outputs of similar age from Endocrine
#43
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