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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Chemical Re-engineering of Chlorotoxin Improves Bioconjugation Properties for Tumor Imaging and Targeted Therapy
|
|---|---|
| Published in |
Journal of Medicinal Chemistry, January 2011
|
| DOI | 10.1021/jm101018r |
| Pubmed ID | |
| Authors |
Muharrem Akcan, Mark R. Stroud, Stacey J. Hansen, Richard J. Clark, Norelle L. Daly, David J. Craik, James M. Olson |
| Abstract |
Bioconjugates composed of chlorotoxin and near-infrared fluorescent (NIRF) moieties are being advanced toward human clinical trials as intraoperative imaging agents that will enable surgeons to visualize small foci of cancer. In previous studies, the NIRF molecules were conjugated to chlorotoxin, which results in a mixture of mono-, di-, and trilabeled peptide. Here we report a new chemical entity that bound only a single NIRF molecule. The lysines at positions 15 and 23 were substituted with either alanine or arginine, which resulted in only monolabeled peptide that was functionally equivalent to native chlorotoxin/Cy5.5. We also analyzed the serum stability and serum half-life of cyclized chlorotoxin, which showed an 11 h serum half-life and resulted in a monolabeled product. Based on these data, we propose to advance a monolabeled chlorotoxin to human clinical trials. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Peru | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| United States | 2 | 2% |
| France | 1 | 1% |
| Unknown | 82 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 20% |
| Student > Ph. D. Student | 16 | 18% |
| Student > Master | 11 | 13% |
| Other | 8 | 9% |
| Student > Doctoral Student | 7 | 8% |
| Other | 16 | 18% |
| Unknown | 12 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 22 | 25% |
| Agricultural and Biological Sciences | 19 | 22% |
| Biochemistry, Genetics and Molecular Biology | 12 | 14% |
| Medicine and Dentistry | 6 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Other | 7 | 8% |
| Unknown | 16 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2023.
All research outputs
#3,008,103
of 23,578,918 outputs
Outputs from Journal of Medicinal Chemistry
#2,890
of 22,400 outputs
Outputs of similar age
#18,309
of 184,127 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#21
of 101 outputs
Altmetric has tracked 23,578,918 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,400 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,127 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.