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Mendeley readers
Attention Score in Context
| Title |
Respiratory syncytial virus infection augments NOD2 signaling in an IFN‐β‐dependent manner in human primary cells
|
|---|---|
| Published in |
European Journal of Immunology, August 2012
|
| DOI | 10.1002/eji.201242396 |
| Pubmed ID | |
| Authors |
Marloes Vissers, Thijs Remijn, Marije Oosting, Dirk J. de Jong, Dimitri A. Diavatopoulos, Peter W.M. Hermans, Gerben Ferwerda |
| Abstract |
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in infants, with remarkable variability in disease severity. An exaggerated proinflammatory response and influx of leukocytes is part of the pathogenesis of severe RSV disease. Here, we show an increase in proinflammatory cytokine production by human immune cells after stimulation with RSV and muramyl dipeptide (MDP), which is recognized by nucleotide-binding oligomerization domain containing 2 (NOD2). PBMCs from Crohn's disease patients homozygous for the 3020insC mutation in the NOD2 gene did not show a synergistic response to stimulation with RSV and MDP, suggesting that NOD2 is essential for the observed synergy. Further experiments aimed at identifying the viral ligand indicated that viral RNA plays an essential role in the recognition of RSV. Stimulation with RSV or Poly(I:C) induced IFN-β expression, which resulted in an increased expression of the viral receptors TLR3 and RIG-I, as well as an increased NOD2 expression. Our data indicate that IFN-β induction by viral RNA is an essential first step in the increased proinflammatory response to MDP. We hypothesize that the enhanced proinflammatory response to MDP following RSV infection may be an important factor in determining the outcome of the severity of disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 55 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 25% |
| Student > Master | 12 | 21% |
| Researcher | 5 | 9% |
| Student > Doctoral Student | 3 | 5% |
| Student > Bachelor | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 11 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 14 | 25% |
| Agricultural and Biological Sciences | 11 | 20% |
| Medicine and Dentistry | 9 | 16% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 11 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2013.
All research outputs
#19,917,373
of 24,477,448 outputs
Outputs from European Journal of Immunology
#6,314
of 6,798 outputs
Outputs of similar age
#135,599
of 174,688 outputs
Outputs of similar age from European Journal of Immunology
#39
of 51 outputs
Altmetric has tracked 24,477,448 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,798 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,688 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.