Title |
The Effects of Alteplase 3 to 6 Hours After Stroke in the EPITHET–DEFUSE Combined Dataset
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Published in |
Stroke, December 2012
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DOI | 10.1161/strokeaha.112.668301 |
Pubmed ID | |
Authors |
Toshiyasu Ogata, Soren Christensen, Yoshinari Nagakane, Henry Ma, Bruce C.V. Campbell, Leonid Churilov, Maarten G. Lansberg, Matus Straka, Deidre A. De Silva, Michael Mlynash, Roland Bammer, Jean-Marc Olivot, Patricia M. Desmond, Gregory W. Albers, Stephen M. Davis, Geoffrey A. Donnan |
Abstract |
Two phase 2 studies of alteplase in acute ischemic stroke 3 to 6 hours after onset, Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET; a randomized, controlled, double-blinded trial), and Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution Study (DEFUSE; open-label, treatment only) using MR imaging-based outcomes have been conducted. We have pooled individual patient data from these to assess the response to alteplase. The primary hypothesis was that alteplase would significantly attenuate infarct growth compared with placebo in mismatch-selected patients using coregistration techniques. |
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Mendeley readers
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