Chapter title |
Antioxidant and anti-inflammatory properties of curcumin.
|
---|---|
Chapter number | 3 |
Book title |
The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
|
Published in |
Advances in experimental medicine and biology, June 2007
|
DOI | 10.1007/978-0-387-46401-5_3 |
Pubmed ID | |
Book ISBNs |
978-0-387-46400-8, 978-0-387-46401-5
|
Authors |
Menon VP, Sudheer AR, Venugopal P. Menon, Adluri Ram Sudheer, Menon, Venugopal P., Sudheer, Adluri Ram |
Editors |
Bharat B. Aggarwal Ph.D., Young-Joon Surh Ph.D., Shishir Shishodia Ph.D. |
Abstract |
Curcumin, a yellow pigment from Curcuma longa, is a major component of turmeric and is commonly used as a spice and food-coloring agent. It is also used as a cosmetic and in some medical preparations. The desirable preventive or putative therapeutic properties of curcumin have also been considered to be associated with its antioxidant and anti-inflammatory properties. Because free-radical-mediated peroxidation of membrane lipids and oxidative damage of DNA and proteins are believed to be associated with a variety of chronic pathological complications such as cancer, atherosclerosis, and neurodegenerative diseases, curcumin is thought to play a vital role against these pathological conditions. The anti-inflammatory effect of curcumin is most likely mediated through its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS). COX-2, LOX, and iNOS are important enzymes that mediate inflammatory processes. Improper upregulation of COX-2 and/or iNOS has been associated with the pathophysiology of certain types of human cancer as well as inflammatory disorders. Because inflammation is closely linked to tumor promotion, curcumin with its potent anti-inflammatory property is anticipated to exert chemopreventive effects on carcinogenesis. Hence, the past few decades have witnessed intense research devoted to the antioxidant and anti-inflammatory properties of curcumin. In this review, we describe both antioxidant and anti-inflammatory properties of curcumin, the mode of action of curcumin, and its therapeutic usage against different pathological conditions. |
X Demographics
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India | 2 | 8% |
United Kingdom | 2 | 8% |
Kuwait | 1 | 4% |
Mongolia | 1 | 4% |
Spain | 1 | 4% |
Canada | 1 | 4% |
Luxembourg | 1 | 4% |
Unknown | 9 | 38% |
Demographic breakdown
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Practitioners (doctors, other healthcare professionals) | 6 | 25% |
Scientists | 1 | 4% |
Mendeley readers
Geographical breakdown
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---|---|---|
United Kingdom | 2 | <1% |
India | 1 | <1% |
Canada | 1 | <1% |
Iceland | 1 | <1% |
Nigeria | 1 | <1% |
United States | 1 | <1% |
Unknown | 969 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 143 | 15% |
Student > Master | 135 | 14% |
Student > Ph. D. Student | 113 | 12% |
Researcher | 77 | 8% |
Student > Doctoral Student | 42 | 4% |
Other | 146 | 15% |
Unknown | 320 | 33% |
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---|---|---|
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Biochemistry, Genetics and Molecular Biology | 98 | 10% |
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Chemistry | 74 | 8% |
Other | 146 | 15% |
Unknown | 361 | 37% |