| Title |
How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, December 2012
|
| DOI | 10.1007/s00018-012-1227-7 |
| Pubmed ID | |
| Authors |
Yoshifumi Yamaguchi, Masayuki Miura |
| Abstract |
The development of the embryonic brain critically depends on successfully completing cranial neural tube closure (NTC). Failure to properly close the neural tube results in significant and potentially lethal neural tube defects (NTDs). We believe these malformations are caused by disruptions in normal developmental programs such as those involved in neural plate morphogenesis and patterning, tissue fusion, and coordinated cell behaviors. Cranial NTDs include anencephaly and craniorachischisis, both lethal human birth defects. Newly emerging methods for molecular and cellular analysis offer a deeper understanding of not only the developmental NTC program itself but also mechanical and kinetic aspects of closure that may contribute to cranial NTDs. Clarifying the underlying mechanisms involved in NTC and how they relate to the onset of specific NTDs in various experimental models may help us develop novel intervention strategies to prevent NTDs. |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Uruguay | 1 | <1% |
| Unknown | 134 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 31 | 23% |
| Student > Ph. D. Student | 22 | 16% |
| Researcher | 17 | 13% |
| Student > Master | 17 | 13% |
| Student > Doctoral Student | 6 | 4% |
| Other | 17 | 13% |
| Unknown | 26 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 29% |
| Biochemistry, Genetics and Molecular Biology | 37 | 27% |
| Neuroscience | 11 | 8% |
| Medicine and Dentistry | 8 | 6% |
| Immunology and Microbiology | 2 | 1% |
| Other | 9 | 7% |
| Unknown | 30 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#5,496,406
of 26,017,215 outputs
Outputs from Cellular and Molecular Life Sciences
#1,210
of 6,041 outputs
Outputs of similar age
#52,871
of 293,277 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#7
of 28 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,041 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,277 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.