| Title |
Modulation of tendon healing by nitric oxide
|
|---|---|
| Published in |
Inflammation Research, January 1997
|
| DOI | 10.1007/s000110050027 |
| Pubmed ID | |
| Authors |
G. A. C. Murrell, C. Szabo, J. A. Hannafin, D. Jang, M. M. Dolan, X.-H. Deng, D. F. Murrell, R. F. Warren |
| Abstract |
Nitric oxide (NO) is a small, diffusible free radical that is generated from L-arginine by a family of enzymes, collectively termed the nitric oxide synthases. We investigated the role of NO in tendon healing. NO synthase activity and immunoreactivity was absent in un-injured rat Achilles tendon. After surgical division there was a five-fold increase in NO synthase activity and immunoreactivity within the healing tendon at day 7, with a return to near baseline levels at day 14. Inhibition of NO synthase activity with oral administration of N omega-nitro-L-arginine methyl ester (L-NAME) resulted in a significant reduction in cross-sectional area (30% at day 7, p < 0.01, 50% at day 15, p < 0.001) and failure load (24% at day 7, p < 0.01) of the healing Achilles tendon constructs. Rats fed the same regimen of the enantiomer of L-NAME, (D-NAME) had normal tendon healing. These results indicate that nitric oxide synthase is induced during tendon healing and inhibition of nitric oxide synthase inhibits this tendon healing. |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 2% |
| Unknown | 51 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 15% |
| Other | 6 | 12% |
| Student > Doctoral Student | 6 | 12% |
| Student > Ph. D. Student | 5 | 10% |
| Student > Master | 4 | 8% |
| Other | 11 | 21% |
| Unknown | 12 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 33% |
| Nursing and Health Professions | 5 | 10% |
| Agricultural and Biological Sciences | 5 | 10% |
| Sports and Recreations | 3 | 6% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Other | 4 | 8% |
| Unknown | 15 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2018.
All research outputs
#7,487,068
of 22,886,568 outputs
Outputs from Inflammation Research
#242
of 958 outputs
Outputs of similar age
#19,807
of 91,705 outputs
Outputs of similar age from Inflammation Research
#1
of 6 outputs
Altmetric has tracked 22,886,568 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 958 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
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