Title |
Heart Failure as a Risk Factor for Osteoporosis and Fractures
|
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Published in |
Current Osteoporosis Reports, August 2012
|
DOI | 10.1007/s11914-012-0115-2 |
Pubmed ID | |
Authors |
Aloice O. Aluoch, Ryan Jessee, Hani Habal, Melinda Garcia-Rosell, Rehan Shah, Guy Reed, Laura Carbone |
Abstract |
Although heart failure (HF) and osteoporosis are common diseases, particularly in elderly populations, patients with HF have an increased risk for osteoporosis. The relationship of HF with osteoporosis is modified by gender and the severity of HF. In addition, shared risk factors, medication use, and common pathogenic mechanisms affect both HF and osteoporosis. Shared risk factors for these 2 conditions include advanced age, hypovitaminosis D, renal disease, and diabetes mellitus. Medications used to treat HF, including spironolactone, thiazide diuretics, nitric oxide donors, and aspirin, may protect against osteoporosis. In contrast, loop diuretics may make osteoporosis worse. HF and osteoporosis appear to share common pathogenic mechanisms, including activation of the renin-angiotensin-aldosterone system, increased parathyroid hormone levels, and/or oxidative/nitrosative stress. HF is a major risk factor for mortality following fractures. Thus, in HF patients, it is important to carefully assess osteoporosis and take measures to reduce the risk of osteoporotic fractures. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Unknown | 55 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 12 | 21% |
Student > Ph. D. Student | 8 | 14% |
Researcher | 7 | 12% |
Unspecified | 5 | 9% |
Student > Doctoral Student | 4 | 7% |
Other | 11 | 19% |
Unknown | 10 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 40% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Agricultural and Biological Sciences | 5 | 9% |
Unspecified | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 7 | 12% |
Unknown | 12 | 21% |