| Title |
Oral Human Immunoglobulin for Children with Autism and Gastrointestinal Dysfunction: A Prospective, Open-Label Study
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, July 2006
|
| DOI | 10.1007/s10803-006-0141-y |
| Pubmed ID | |
| Authors |
Cindy K. Schneider, Raun D. Melmed, Leon E. Barstow, F. Javier Enriquez, James Ranger-Moore, James A. Ostrem |
| Abstract |
Immunoglobulin secretion onto mucosal surfaces is a major component of the mucosal immune system. We hypothesized that chronic gastrointestinal (GI) disturbances associated with autistic disorder (AD) may be due to an underlying deficiency in mucosal immunity, and that orally administered immunoglobulin would be effective in alleviating chronic GI dysfunction in these individuals. In this pilot study, twelve male subjects diagnosed with AD were evaluated using a GI severity index (GSI) while receiving daily dosing with encapsulated human immunoglobulin. Following eight weeks of treatment, 50% of the subjects met prespecified criteria for response in GI signs and symptoms and showed significant behavioral improvement as assessed by the Autism Behavior Checklist and parent and physician rated Clinical Global Impression of Improvement. |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | <1% |
| Unknown | 102 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 16 | 16% |
| Student > Master | 13 | 13% |
| Student > Ph. D. Student | 12 | 12% |
| Student > Bachelor | 11 | 11% |
| Researcher | 11 | 11% |
| Other | 23 | 22% |
| Unknown | 17 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 25% |
| Psychology | 16 | 16% |
| Nursing and Health Professions | 7 | 7% |
| Agricultural and Biological Sciences | 7 | 7% |
| Neuroscience | 7 | 7% |
| Other | 18 | 17% |
| Unknown | 22 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2024.
All research outputs
#3,827,310
of 23,867,274 outputs
Outputs from Journal of Autism and Developmental Disorders
#1,555
of 5,240 outputs
Outputs of similar age
#9,957
of 67,467 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#10
of 39 outputs
Altmetric has tracked 23,867,274 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,240 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 67,467 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.