| Title |
Pathogenesis and treatment of ANCA-associated vasculitis—a role for complement
|
|---|---|
| Published in |
Pediatric Nephrology, September 2016
|
| DOI | 10.1007/s00467-016-3475-5 |
| Pubmed ID | |
| Authors |
Damien Noone, Diane Hebert, Christoph Licht |
| Abstract |
The antineutrophil cytoplasm autoantibody (ANCA)-associated vasculitides (AAV), although rare in childhood, can have devastating effects on affected organs, especially the kidney. In this review we present an update on the pathogenesis and treatment of ANCA vasculitis, with a particular emphasis on the role of the alternative pathway of complement. The rationale and evidence for the current treatment strategies are summarized. Targeting the activation of neutrophils by the anaphylatoxin C5a may serve as an additional therapeutic strategy, however the results of clinical studies are awaited. |
X Demographics
The data shown below were collected from the profiles of 46 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 11 | 24% |
| Mexico | 3 | 7% |
| United Kingdom | 3 | 7% |
| United States | 3 | 7% |
| Spain | 2 | 4% |
| Indonesia | 2 | 4% |
| Australia | 1 | 2% |
| Ecuador | 1 | 2% |
| Turkey | 1 | 2% |
| Other | 6 | 13% |
| Unknown | 13 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 25 | 54% |
| Practitioners (doctors, other healthcare professionals) | 11 | 24% |
| Scientists | 7 | 15% |
| Science communicators (journalists, bloggers, editors) | 3 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 58 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 18% |
| Other | 10 | 17% |
| Student > Postgraduate | 7 | 12% |
| Student > Bachelor | 7 | 12% |
| Student > Ph. D. Student | 6 | 10% |
| Other | 8 | 13% |
| Unknown | 11 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 48% |
| Chemistry | 3 | 5% |
| Immunology and Microbiology | 3 | 5% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 16 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2018.
All research outputs
#1,408,128
of 25,432,721 outputs
Outputs from Pediatric Nephrology
#59
of 4,074 outputs
Outputs of similar age
#25,290
of 346,156 outputs
Outputs of similar age from Pediatric Nephrology
#2
of 59 outputs
Altmetric has tracked 25,432,721 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,074 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,156 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.