Title |
Maintenance, reduction, or withdrawal of etanercept after treatment with etanercept and methotrexate in patients with moderate rheumatoid arthritis (PRESERVE): a randomised controlled trial
|
---|---|
Published in |
The Lancet, January 2013
|
DOI | 10.1016/s0140-6736(12)61811-x |
Pubmed ID | |
Authors |
Josef S Smolen, Peter Nash, Patrick Durez, Stephen Hall, Elena Ilivanova, Fedra Irazoque-Palazuelos, Pedro Miranda, Min-Chan Park, Karel Pavelka, Ronald Pedersen, Annette Szumski, Constance Hammond, Andrew S Koenig, Bonnie Vlahos |
Abstract |
Clinical remission and low disease activity are essential treatment targets in patients with rheumatoid arthritis. Although moderately active rheumatoid arthritis is common, treatment effects in moderate disease have not been well studied. Additionally, optimum use of biologics needs further investigation, including the use of induction, maintenance, and withdrawal treatment strategies. The aim of the PRESERVE trial was to assess whether low disease activity would be sustained with reduced doses or withdrawal of etanercept in patients with moderately active disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 13% |
France | 2 | 9% |
Japan | 1 | 4% |
Ecuador | 1 | 4% |
Argentina | 1 | 4% |
United Kingdom | 1 | 4% |
Spain | 1 | 4% |
Venezuela, Bolivarian Republic of | 1 | 4% |
Australia | 1 | 4% |
Other | 0 | 0% |
Unknown | 11 | 48% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 18 | 78% |
Practitioners (doctors, other healthcare professionals) | 4 | 17% |
Scientists | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
Germany | 1 | <1% |
Switzerland | 1 | <1% |
Netherlands | 1 | <1% |
Paraguay | 1 | <1% |
Canada | 1 | <1% |
Singapore | 1 | <1% |
Argentina | 1 | <1% |
Japan | 1 | <1% |
Other | 1 | <1% |
Unknown | 224 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 40 | 17% |
Other | 25 | 11% |
Student > Bachelor | 23 | 10% |
Student > Ph. D. Student | 22 | 9% |
Student > Postgraduate | 18 | 8% |
Other | 60 | 26% |
Unknown | 46 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 129 | 55% |
Biochemistry, Genetics and Molecular Biology | 11 | 5% |
Agricultural and Biological Sciences | 9 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 4% |
Nursing and Health Professions | 7 | 3% |
Other | 16 | 7% |
Unknown | 53 | 23% |