| Title |
Development of raloxifene-solid dispersion with improved oral bioavailability via spray-drying technique
|
|---|---|
| Published in |
Archives of Pharmacal Research, January 2013
|
| DOI | 10.1007/s12272-013-0012-y |
| Pubmed ID | |
| Authors |
Tuan Hiep Tran, Bijay Kumar Poudel, Nirmal Marasini, Jong Soo Woo, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim |
| Abstract |
The purpose of this study was to develop a raloxifene-loaded solid dispersion with enhanced dissolution rate and bioavailability via spray-drying technique. Solid dispersions of raloxifene (RXF) were prepared with PVP K30 at weight ratios of 1:4, 1:6 and 1:8 using a spray-drying method, and characterized by differential scanning calorimetry, X-ray powder diffraction, scanning electron microscopy, and solubility and dissolution tests. The bioavailability of the solid dispersion in rats was also evaluated compared to those of RXF powder and commercial product. Results showed that the RXF-loaded solid dispersion was in amorphous form with increased solubility and dissolution rate. The absorption of RXF from solid dispersion resulted in approximately 2.6-fold enhanced bioavailability compared to pure drug. Moreover, RXF-loaded solid dispersion gave similar AUC, C(max) and T(max) values to the commercial product, suggesting that it was bioequivalent to the commercial product in rats. These findings suggest that an amorphous solid dispersion of RXF could be a viable option for enhancing the oral bioavailability of RXF. |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 3% |
| India | 1 | 3% |
| Unknown | 38 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 20% |
| Student > Ph. D. Student | 4 | 10% |
| Researcher | 3 | 8% |
| Student > Bachelor | 3 | 8% |
| Lecturer > Senior Lecturer | 2 | 5% |
| Other | 11 | 28% |
| Unknown | 9 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 38% |
| Medicine and Dentistry | 4 | 10% |
| Agricultural and Biological Sciences | 2 | 5% |
| Immunology and Microbiology | 2 | 5% |
| Chemistry | 2 | 5% |
| Other | 5 | 13% |
| Unknown | 10 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2020.
All research outputs
#5,204,235
of 24,541,341 outputs
Outputs from Archives of Pharmacal Research
#179
of 1,354 outputs
Outputs of similar age
#54,538
of 294,148 outputs
Outputs of similar age from Archives of Pharmacal Research
#10
of 35 outputs
Altmetric has tracked 24,541,341 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,354 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,148 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.