↓ Skip to main content

Is High Dose Vitamin D Harmful?

Overview of attention for article published in Calcified Tissue International, December 2012
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
policy
1 policy source
twitter
7 X users
facebook
2 Facebook pages
googleplus
1 Google+ user
video
1 YouTube creator

Citations

dimensions_citation
82 Dimensions

Readers on

mendeley
86 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Is High Dose Vitamin D Harmful?
Published in
Calcified Tissue International, December 2012
DOI 10.1007/s00223-012-9679-1
Pubmed ID
Authors

Kerrie M. Sanders, Geoffrey C. Nicholson, Peter R. Ebeling

Abstract

With the potential to minimize the risk of many chronic diseases and the apparent biochemical safety of ingesting doses of oral vitamin D several-fold higher than the current recommended intakes, recent research has focussed on supplementing individuals with intermittent, high-dose vitamin D. However, two recent randomized controlled trials (RCTs) both using annual high-dose vitamin D reported an increase, rather than a decrease, in the primary outcome of fractures. This review summarises the results from studies that have used intermittent, high doses of vitamin D, with particular attention to those finding evidence of adverse effects. Results from observational, population-based studies with evidence of a U- or J-shaped curve are also presented as these findings suggest an increased risk in those with the highest serum 25D levels. Speculative mechanisms are discussed and biochemical results from studies using high-dose vitamin D are also presented. Emerging evidence from both observational studies and RCTs suggests there should be a degree of caution about recommending high serum 25D concentrations for the entire population. Furthermore, benefit of the higher doses commonly used in clinical practice on falls risk reduction needs to be demonstrated. The safety of loading doses of vitamin D should be demonstrated before these regimens become recommended as routine clinical practice. The current dilemma of defining vitamin D insufficiency and identifying safe and efficacious repletion regimens needs to be resolved.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
Brazil 1 1%
Unknown 84 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 15%
Other 10 12%
Student > Ph. D. Student 10 12%
Student > Bachelor 9 10%
Researcher 7 8%
Other 25 29%
Unknown 12 14%
Readers by discipline Count As %
Medicine and Dentistry 40 47%
Nursing and Health Professions 6 7%
Agricultural and Biological Sciences 5 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Unspecified 3 3%
Other 12 14%
Unknown 17 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2021.
All research outputs
#1,379,048
of 23,685,936 outputs
Outputs from Calcified Tissue International
#63
of 1,813 outputs
Outputs of similar age
#12,577
of 284,673 outputs
Outputs of similar age from Calcified Tissue International
#2
of 19 outputs
Altmetric has tracked 23,685,936 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,813 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,673 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.