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Stressful life events and the risk of initial central nervous system demyelination

Overview of attention for article published in Multiple Sclerosis Journal, September 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

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Title
Stressful life events and the risk of initial central nervous system demyelination
Published in
Multiple Sclerosis Journal, September 2016
DOI 10.1177/1352458516667566
Pubmed ID
Authors

Alice Saul, Anne-Louise Ponsonby, Robyn M Lucas, Bruce V Taylor, Steve Simpson, Patricia Valery, Terence Dwyer, Trevor J Kilpatrick, Michael P Pender, Ingrid AF van der Mei

Abstract

There is substantial evidence that stress increases multiple sclerosis disease activity, but limited evidence on its association with the onset of multiple sclerosis. To examine the association between stressful life events and risk of first demyelinating event (FDE). This was a multicentre incident case-control study. Cases (n = 282 with first diagnosis of central nervous system (CNS) demyelination, including n = 216 with 'classic FDE') were aged 18-59 years. Controls without CNS demyelination (n = 558) were matched to cases on age, sex and study region. Stressful life events were assessed using a questionnaire based on the Social Readjustment Rating Scale. Those who suffered from a serious illness in the previous 12 months were more likely to have an FDE (odds ratio (OR) = 2.35 (1.36, 4.06), p = 0.002), and when we limited our reference group to those who had no stressful life events, the magnitude of effect became stronger (OR = 5.41 (1.80, 16.28)). The total stress number and stress load were not convincingly associated with the risk of an FDE. Cases were more likely to report a serious illness in the previous 12 months, which could suggest that a non-specific illness provides an additional strain to an already predisposed immune system.

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X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 18%
Other 4 12%
Researcher 4 12%
Professor > Associate Professor 3 9%
Professor 2 6%
Other 7 21%
Unknown 7 21%
Readers by discipline Count As %
Medicine and Dentistry 8 24%
Neuroscience 6 18%
Psychology 4 12%
Social Sciences 3 9%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 2 6%
Unknown 9 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2023.
All research outputs
#4,566,398
of 25,503,365 outputs
Outputs from Multiple Sclerosis Journal
#1,361
of 3,727 outputs
Outputs of similar age
#70,777
of 345,153 outputs
Outputs of similar age from Multiple Sclerosis Journal
#21
of 76 outputs
Altmetric has tracked 25,503,365 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,727 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,153 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.