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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis
|
|---|---|
| Published in |
Nature Biotechnology, January 2013
|
| DOI | 10.1038/nbt.2487 |
| Pubmed ID | |
| Authors |
Yun Liu, Martin J Aryee, Leonid Padyukov, M Daniele Fallin, Espen Hesselberg, Arni Runarsson, Lovisa Reinius, Nathalie Acevedo, Margaret Taub, Marcus Ronninger, Klementy Shchetynsky, Annika Scheynius, Juha Kere, Lars Alfredsson, Lars Klareskog, Tomas J Ekström, Andrew P Feinberg |
| Abstract |
Epigenetic mechanisms integrate genetic and environmental causes of disease, but comprehensive genome-wide analyses of epigenetic modifications have not yet demonstrated robust association with common diseases. Using Illumina HumanMethylation450 arrays on 354 anti-citrullinated protein antibody-associated rheumatoid arthritis cases and 337 controls, we identified two clusters within the major histocompatibility complex (MHC) region whose differential methylation potentially mediates genetic risk for rheumatoid arthritis. To reduce confounding factors that have hampered previous epigenome-wide studies, we corrected for cellular heterogeneity by estimating and adjusting for cell-type proportions in our blood-derived DNA samples and used mediation analysis to filter out associations likely to be a consequence of disease. Four CpGs also showed an association between genotype and variance of methylation. The associations for both clusters replicated at least one CpG (P < 0.01), with the rest showing suggestive association, in monocyte cell fractions in an independent cohort of 12 cases and 12 controls. Thus, DNA methylation is a potential mediator of genetic risk. |
X Demographics
The data shown below were collected from the profiles of 64 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 16 | 25% |
| United Kingdom | 6 | 9% |
| Germany | 2 | 3% |
| New Zealand | 1 | 2% |
| Canada | 1 | 2% |
| Paraguay | 1 | 2% |
| Singapore | 1 | 2% |
| Finland | 1 | 2% |
| India | 1 | 2% |
| Other | 6 | 9% |
| Unknown | 28 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 40 | 63% |
| Scientists | 20 | 31% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
| Practitioners (doctors, other healthcare professionals) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 854 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 2% |
| United Kingdom | 8 | <1% |
| Sweden | 3 | <1% |
| Spain | 2 | <1% |
| Norway | 2 | <1% |
| Brazil | 2 | <1% |
| Germany | 1 | <1% |
| Ireland | 1 | <1% |
| Israel | 1 | <1% |
| Other | 10 | 1% |
| Unknown | 811 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 225 | 26% |
| Researcher | 188 | 22% |
| Student > Bachelor | 71 | 8% |
| Student > Master | 61 | 7% |
| Professor > Associate Professor | 44 | 5% |
| Other | 155 | 18% |
| Unknown | 110 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 284 | 33% |
| Biochemistry, Genetics and Molecular Biology | 170 | 20% |
| Medicine and Dentistry | 102 | 12% |
| Computer Science | 32 | 4% |
| Immunology and Microbiology | 29 | 3% |
| Other | 93 | 11% |
| Unknown | 144 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 68. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2023.
All research outputs
#639,188
of 25,837,817 outputs
Outputs from Nature Biotechnology
#1,343
of 8,607 outputs
Outputs of similar age
#4,785
of 299,602 outputs
Outputs of similar age from Nature Biotechnology
#13
of 106 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,607 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,602 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.