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Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

Overview of attention for article published in Nature Biotechnology, January 2013
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
64 X users
patent
8 patents
facebook
1 Facebook page

Citations

dimensions_citation
837 Dimensions

Readers on

mendeley
843 Mendeley
citeulike
7 CiteULike
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Title
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis
Published in
Nature Biotechnology, January 2013
DOI 10.1038/nbt.2487
Pubmed ID
Authors

Yun Liu, Martin J Aryee, Leonid Padyukov, M Daniele Fallin, Espen Hesselberg, Arni Runarsson, Lovisa Reinius, Nathalie Acevedo, Margaret Taub, Marcus Ronninger, Klementy Shchetynsky, Annika Scheynius, Juha Kere, Lars Alfredsson, Lars Klareskog, Tomas J Ekström, Andrew P Feinberg

Abstract

Epigenetic mechanisms integrate genetic and environmental causes of disease, but comprehensive genome-wide analyses of epigenetic modifications have not yet demonstrated robust association with common diseases. Using Illumina HumanMethylation450 arrays on 354 anti-citrullinated protein antibody-associated rheumatoid arthritis cases and 337 controls, we identified two clusters within the major histocompatibility complex (MHC) region whose differential methylation potentially mediates genetic risk for rheumatoid arthritis. To reduce confounding factors that have hampered previous epigenome-wide studies, we corrected for cellular heterogeneity by estimating and adjusting for cell-type proportions in our blood-derived DNA samples and used mediation analysis to filter out associations likely to be a consequence of disease. Four CpGs also showed an association between genotype and variance of methylation. The associations for both clusters replicated at least one CpG (P < 0.01), with the rest showing suggestive association, in monocyte cell fractions in an independent cohort of 12 cases and 12 controls. Thus, DNA methylation is a potential mediator of genetic risk.

X Demographics

X Demographics

The data shown below were collected from the profiles of 64 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 843 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 13 2%
United Kingdom 8 <1%
Sweden 3 <1%
Spain 2 <1%
Norway 2 <1%
Brazil 2 <1%
Germany 1 <1%
Ireland 1 <1%
Israel 1 <1%
Other 10 1%
Unknown 800 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 225 27%
Researcher 188 22%
Student > Bachelor 68 8%
Student > Master 61 7%
Professor > Associate Professor 44 5%
Other 148 18%
Unknown 109 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 284 34%
Biochemistry, Genetics and Molecular Biology 164 19%
Medicine and Dentistry 100 12%
Computer Science 32 4%
Immunology and Microbiology 29 3%
Other 91 11%
Unknown 143 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 69. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2023.
All research outputs
#616,414
of 25,255,356 outputs
Outputs from Nature Biotechnology
#1,302
of 8,776 outputs
Outputs of similar age
#4,746
of 298,098 outputs
Outputs of similar age from Nature Biotechnology
#13
of 106 outputs
Altmetric has tracked 25,255,356 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,776 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.0. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,098 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.