Title |
Pheromonal bile acid 3-ketopetromyzonol sulfate primes the neuroendocrine system in sea lamprey
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Published in |
BMC Neuroscience, January 2013
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DOI | 10.1186/1471-2202-14-11 |
Pubmed ID | |
Authors |
Yu-Wen Chung-Davidson, Huiyong Wang, Michael J Siefkes, Mara B Bryan, Hong Wu, Nicholas S Johnson, Weiming Li |
Abstract |
Vertebrate pheromones are known to prime the endocrine system, especially the hypothalamic-pituitary-gonadal (HPG) axis. However, no known pheromone molecule has been shown to modulate directly the synthesis or release of gonadotropin releasing hormone (GnRH), the main regulator of the HPG axis. We selected sea lamprey (Petromyzon marinus) as a model system to determine whether a single pheromone component alters the output of GnRH.Sea lamprey male sex pheromones contain a main component, 7α, 12α, 24-trihydroxy-5α-cholan-3-one 24-sulfate (3 keto-petromyzonol sulfate or 3kPZS), which has been shown to modulate behaviors of mature females. Through a series of experiments, we tested the hypothesis that 3kPZS modulates both synthesis and release of GnRH, and subsequently, HPG output in immature sea lamprey. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 7% |
Unknown | 13 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor > Associate Professor | 3 | 21% |
Researcher | 3 | 21% |
Student > Ph. D. Student | 2 | 14% |
Student > Master | 2 | 14% |
Student > Bachelor | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 21% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 43% |
Medicine and Dentistry | 2 | 14% |
Environmental Science | 1 | 7% |
Neuroscience | 1 | 7% |
Chemistry | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 21% |