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Spermine reduces reactive oxygen species levels and decreases cryocapacitation in canine sperm cryopreservation

Overview of attention for article published in Biochemical & Biophysical Research Communications, August 2016
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Title
Spermine reduces reactive oxygen species levels and decreases cryocapacitation in canine sperm cryopreservation
Published in
Biochemical & Biophysical Research Communications, August 2016
DOI 10.1016/j.bbrc.2016.08.091
Pubmed ID
Authors

Erif Maha Nugraha Setyawan, Min Jung Kim, Hyun Ju Oh, Geon A. Kim, Young Kwang Jo, Seok Hee Lee, Yoo Bin Choi, Byeong Chun Lee

Abstract

The objective of this study was to determine the ability of spermine to act as an antioxidant in scavenging reactive oxygen species (ROS), maintaining sperm function and decreasing cryocapacitation after cryopreservation. Although motility did not increase with spermine treatment, values for membrane integrity were significantly increased (P < 0.05). Higher percentages of linearity and straightness with a lower amplitude of lateral head displacement (ALH) indicated that spermine inhibits hyperactivation. Concentrations of intracellular and extracellular ROS were decreased in the treatment group (P < 0.05). Higher expression of an anti-apoptotic gene (Bcl-2) and lower expression of a pro-apoptotic gene (Bax), together with decreased expression of the mitochondrial ROS modulator ROMO1, DNA repair due to oxidative damage (OGG1), spermine synthase (SMS), NADPH oxidase associated with motility (NOX5) and spermine amino oxidase (SMOX), all showed that 5.0 mM spermine treatment was beneficial to spermatozoa. Furthermore, the proportion of live spermatozoa with intact acrosomes after thawing in the treatment group was higher than in the control. After incubation in canine capacitating medium, numbers of live capacitated spermatozoa with reacted acrosomes were higher than in the control. Our results indicate that 5.0 mM spermine is an optimal concentration for maintaining sperm function, reducing ROS production, preventing apoptosis and adverse effects of cryocapacitation during canine sperm cryopreservation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 19%
Student > Ph. D. Student 4 15%
Student > Doctoral Student 4 15%
Student > Master 3 11%
Librarian 1 4%
Other 5 19%
Unknown 5 19%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 8 30%
Agricultural and Biological Sciences 6 22%
Materials Science 2 7%
Biochemistry, Genetics and Molecular Biology 2 7%
Unspecified 1 4%
Other 2 7%
Unknown 6 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2016.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Biochemical & Biophysical Research Communications
#20,346
of 26,637 outputs
Outputs of similar age
#228,040
of 348,145 outputs
Outputs of similar age from Biochemical & Biophysical Research Communications
#110
of 246 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 26,637 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,145 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 246 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.