| Title |
Effect of α7n-Acetylcholine Receptor Activation and Antibodies to TNF-α on Mortality of Mice and Concentration of Proinflammatory Cytokines During Early Stage of Sepsis
|
|---|---|
| Published in |
Bulletin of Experimental Biology and Medicine, November 2015
|
| DOI | 10.1007/s10517-015-3063-x |
| Pubmed ID | |
| Authors |
P. F. Zabrodskii, M. S. Gromov, V. V. Maslyakov |
| Abstract |
Experiments on random-bred albino mice showed that activation α7n-acetylcholine receptors with anabasine (0.5 LD50) and the use of antibodies to TNF-α (1 mg/kg) 2 h before sepsis modeling significantly reduces mortality of mice from experimental sepsis (intraperitoneal injection of E. coli) due to a decrease in the blood concentration of proinflammatory cytokines TNF-α, IL-1β, and IL-6. After combined administration of anti-TNF-α antibodies and anabasine, an additive effect was observed. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 1 | 13% |
| Professor | 1 | 13% |
| Student > Ph. D. Student | 1 | 13% |
| Professor > Associate Professor | 1 | 13% |
| Student > Bachelor | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 3 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Arts and Humanities | 1 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 13% |
| Nursing and Health Professions | 1 | 13% |
| Agricultural and Biological Sciences | 1 | 13% |
| Immunology and Microbiology | 1 | 13% |
| Other | 1 | 13% |
| Unknown | 2 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2016.
All research outputs
#15,907,830
of 24,217,893 outputs
Outputs from Bulletin of Experimental Biology and Medicine
#572
of 1,357 outputs
Outputs of similar age
#162,797
of 290,036 outputs
Outputs of similar age from Bulletin of Experimental Biology and Medicine
#10
of 46 outputs
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So far Altmetric has tracked 1,357 research outputs from this source. They receive a mean Attention Score of 2.3. This one has gotten more attention than average, scoring higher than 56% of its peers.
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We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.