| Title |
Azithromycin Reduces Gastroesophageal Reflux and Aspiration in Lung Transplant Recipients
|
|---|---|
| Published in |
Digestive Diseases and Sciences, February 2009
|
| DOI | 10.1007/s10620-009-0725-4 |
| Pubmed ID | |
| Authors |
V. Mertens, K. Blondeau, A. Pauwels, R. Farre, B. Vanaudenaerde, R. Vos, G. Verleden, D. E. Van Raemdonck, L. J. Dupont, D. Sifrim |
| Abstract |
Azithromycin (AZI) is a macrolide antibiotic that improves lung function in lung transplant recipients (LTx). Gastroesophageal reflux (GER) has been implicated in the pathogenesis of chronic rejection after LTx. Macrolide antibiotics may affect GER by modifying esophageal and gastric motility. The purpose of this study was to evaluate the effect of AZI on GER and gastric aspiration after LTx. Acid and weakly acidic GER was measured with 24-h pH-impedance monitoring in 47 LTx patients (12 patients "on" AZI). Gastric aspiration was assessed in a separate group of 30 LTx patients before and after AZI by measurements of pepsin and bile acid in bronchoalveolar lavage fluid (BALF). Patients "on" AZI had a significant lower total number of reflux events [41 (30-61) vs. 22.5 (7-37.5)], number of acid reflux events [24 (16-41) vs. 8 (4-18)], esophageal acid exposure [2.9% (0.7-7.3) vs. 0.2% (0.1-2.0)], bolus exposure [0.73% (0.5-1.4) vs. 0.21% (0.12-0.92)], and proximal extent of reflux [14 (9-24) vs. 5 (2-7)]. AZI reduced the concentration of bile acids in BALF without affecting levels of pepsin. LTx patients "on" AZI have less GER and bile acids aspiration. This effect might be due to enhanced esophageal motility and accelerated gastric emptying. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 13% |
| Professor > Associate Professor | 4 | 13% |
| Other | 3 | 10% |
| Professor | 2 | 7% |
| Student > Postgraduate | 2 | 7% |
| Other | 8 | 27% |
| Unknown | 7 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 50% |
| Nursing and Health Professions | 3 | 10% |
| Psychology | 1 | 3% |
| Arts and Humanities | 1 | 3% |
| Unknown | 10 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2013.
All research outputs
#16,085,048
of 24,676,547 outputs
Outputs from Digestive Diseases and Sciences
#3,003
of 4,540 outputs
Outputs of similar age
#85,673
of 101,018 outputs
Outputs of similar age from Digestive Diseases and Sciences
#16
of 20 outputs
Altmetric has tracked 24,676,547 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
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